Protein Info for MMJJ_RS08480 in Methanococcus maripaludis JJ

Annotation: hydroxyethylthiazole kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00694: hydroxyethylthiazole kinase
  • amino acids 8 to 252 (245 residues), 303.8 bits, E=4.8e-95
• PF02110: HK
  • amino acids 8 to 252 (245 residues), 270.1 bits, E=8.4e-85

Best Hits

Swiss-Prot: 98% identical to THIM_METMP: Hydroxyethylthiazole kinase (thiM) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00878, hydroxyethylthiazole kinase [EC: 2.7.1.50] (inferred from 98% identity to mmp:MMP1138)

Predicted SEED Role

"Hydroxyethylthiazole kinase (EC 2.7.1.50)" in subsystem Thiamin biosynthesis (EC 2.7.1.50)

MetaCyc Pathways

• thiamine diphosphate salvage II (5/5 steps found)
• thiamine diphosphate salvage V (3/3 steps found)
• thiamine diphosphate salvage IV (yeast) (4/7 steps found)
• thiamine diphosphate formation from pyrithiamine and oxythiamine (yeast) (4/8 steps found)

KEGG Metabolic Maps

• Thiamine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.50

Protein Sequence (266 amino acids)

>MMJJ_RS08480 hydroxyethylthiazole kinase (Methanococcus maripaludis JJ)
MDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGASPVMAHAIDELEEMVSIASAL
VVNIGTLDEYWIPSMEKAAKIASDLKKPIILDPVGAGATKLRTKTALKILDFADISVLRG
NFGEIAAVLGEHGKTRGVDSAAYDNNEAIELSKNAAKEFNTVSAVTGPVDHVSNGKEIYA
ISNGHSMLSKVTGTGCATTSIIGAFSAVDDPLKAAVSGLVVYGISAEMAFNEAPYPGTFQ
AKVYDWLYRIDEKLVLEKAKVNKFEI