Protein Info for MMJJ_RS08420 in Methanococcus maripaludis JJ
Annotation: uroporphyrinogen decarboxylase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 92% identity to mmp:MMP1150)Predicted SEED Role
No annotation
MetaCyc Pathways
- superpathway of heme b biosynthesis from glutamate (7/10 steps found)
- superpathway of heme b biosynthesis from glycine (4/8 steps found)
- heme b biosynthesis I (aerobic) (1/4 steps found)
- heme b biosynthesis II (oxygen-independent) (1/4 steps found)
- heme b biosynthesis V (aerobic) (1/4 steps found)
- heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
- superpathway of heme b biosynthesis from uroporphyrinogen-III (1/6 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (1/9 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (1/9 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (1/9 steps found)
- superpathway of bacteriochlorophyll a biosynthesis (4/26 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.37
Use Curated BLAST to search for 4.1.1.37
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (352 amino acids)
>MMJJ_RS08420 uroporphyrinogen decarboxylase family protein (Methanococcus maripaludis JJ) MEIKKDIMTSKERVAAFLEGKPLDRIVAMPIVTSNTAQLIGKSQKDFQLNSEVMTKSHIA GFEKFGYDLLYLFTNCSYLAEAMGQKLVYFENEPASCRDPVVKTPEDISKINVAEGYEAN LPVYYEAIEMIQKEIGDQVNVAVCFSGPFSTASTLRGHEQFIKDTYNNPELCHELMKMAT ESAKNFITEVVKRGAIPIILEPLSSGSLISPRSFKQFSKPYITELVEHAHELGTIIPLHI CEKTTKIIDQMSETGADVLSIDLCDLEVAKEKVSGKSVILGNVSPSDDLLFGPVERIHET CKNLIEIMDGFKPGFILSTGCETSDKVPMENIQALMDSARYYGVNEDFQNQV