Protein Info for MMJJ_RS08225 in Methanococcus maripaludis JJ

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 PF00254: FKBP_C" amino acids 3 to 86 (84 residues), 67.5 bits, see alignment E=5.3e-23

Best Hits

Swiss-Prot: 66% identical to FKBP_METTL: FKBP-type peptidyl-prolyl cis-trans isomerase from Methanothermococcus thermolithotrophicus

KEGG orthology group: K01802, peptidylprolyl isomerase [EC: 5.2.1.8] (inferred from 99% identity to mmp:MMP1190)

Predicted SEED Role

"FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase or Potassium homeostasis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (150 amino acids)

>MMJJ_RS08225 peptidylprolyl isomerase (Methanococcus maripaludis JJ)
MITKGDTIKVDYTGRFEEGEVFDTSVETVAKEEGIFEEGRPYMPLEFTVGEGQLIQGFEE
AVLGLKIGEEVTVTIPPEKGYGFRDESLIERVPIEAFDQADFEPEEGMVIVAGEEPAVIL
EVTDEDVALDFNHELAGETLQFTIKIIEKL