Protein Info for MMJJ_RS08040 in Methanococcus maripaludis JJ

Annotation: NAD(P)/FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 385 PF01494: FAD_binding_3" amino acids 5 to 288 (284 residues), 30.8 bits, see alignment E=9.3e-12 TIGR02032: geranylgeranyl reductase family" amino acids 6 to 299 (294 residues), 216.9 bits, see alignment E=2.6e-68

Best Hits

Swiss-Prot: 55% identical to Y1520_METJA: Uncharacterized protein MJ1520 (MJ1520) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 96% identity to mmp:MMP1226)

Predicted SEED Role

"Geranylgeranyl/isoprenyl reductase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (385 amino acids)

>MMJJ_RS08040 NAD(P)/FAD-dependent oxidoreductase (Methanococcus maripaludis JJ)
MDFEKYDVVIVGGGPCGFITGENIKNKNVLVLEEHQEIGVPFQCAGLLSKKCINELGNPK
GSVNKVRGAHIYSKNSSITVGNEEIRAEVFERKVMDKDIAVRASKNVDILLKSYGKIKNS
NNLSNRDKCMHNLEIMHIGDTFEISPEIIIGADGIRSTIGRSLNMLDKKREIISGVQIEF
VNAKVDDDFVYVIYDKKYSEKFFTWIIPLGNDRVRVGMCDSNNSYKKLIDFIENNPVAKE
ILKNANPVEFICGAIPIGYSKSVKNNVMLVGDSAGQVKPLSGGGLYYGAKCGKICSDTIN
QYFEGNYDIEFLKNYEKNWKSEISSEIDKNIKIRKILNMINNDKMDRIFDFIDKNNLVEF
INEKGDMDNPSTVVKPILDRVIFGK