Protein Info for MMJJ_RS07475 in Methanococcus maripaludis JJ

Annotation: chorismate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01264: Chorismate_synt
  • amino acids 8 to 363 (356 residues), 441.3 bits, E=7.9e-137
• TIGR00033: chorismate synthase
  • amino acids 8 to 365 (358 residues), 462.1 bits, E=5.4e-143

Best Hits

Swiss-Prot: 97% identical to AROC_METMP: Chorismate synthase (aroC) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01736, chorismate synthase [EC: 4.2.3.5] (inferred from 97% identity to mmp:MMP1333)

Predicted SEED Role

"Chorismate synthase (EC 4.2.3.5)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 4.2.3.5)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (17/18 steps found)
• chorismate biosynthesis II (archaea) (12/12 steps found)
• superpathway of L-tryptophan biosynthesis (12/13 steps found)
• superpathway of L-phenylalanine biosynthesis (9/10 steps found)
• superpathway of L-tyrosine biosynthesis (9/10 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis I (6/7 steps found)
• superpathway of chorismate metabolism (25/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.5

Protein Sequence (373 amino acids)

>MMJJ_RS07475 chorismate synthase (Methanococcus maripaludis JJ)
MNTFGDNFRVTTWGESHGKALGAVVDGCPANLPILEEDIQNELNRRRPGYSIFSTPRKEE
DKVEILSGIFEGKTTGTPISGLVFNKGQKSKDYSKIKDTPRPGHADLNYFLKYGNYDYRG
GGRSSGRTTIGNVIGGAVAKKLIEFTHNIKIIGYSTKIGKIKGDFDYYKNPKFFESDSNI
EKLFEKTENNPLRCPSKNSDEMKNYVLDAMDKKDSVGGIIEIIIKGIPQGVGNPVFNKLE
GKLGSAFIGINAVKGFEIGRGFESSELYGSEMNDEYYIDENSINEKTNNAGGIIGGISTG
SPVVIRVSIKPTPSISKIQDSVNLISNETEKIEIGGRHDPIIVPRVIPVLESMAAITVAD
LMISGGYIHPCRL