Protein Info for MMJJ_RS07440 in Methanococcus maripaludis JJ

Annotation: metallophosphoesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 372 PF00149: Metallophos" amino acids 1 to 193 (193 residues), 62.3 bits, see alignment E=4.3e-21

Best Hits

Swiss-Prot: 98% identical to MRE11_METMP: DNA double-strand break repair protein Mre11 (mre11) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: None (inferred from 98% identity to mmp:MMP1340)

Predicted SEED Role

"DNA double-strand break repair protein Mre11"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (372 amino acids)

>MMJJ_RS07440 metallophosphoesterase (Methanococcus maripaludis JJ)
MQFVHMADNHLGYRQYSLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNA
IRCAMEGLLKLKEKNIPIYLIHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFN
NEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLFHQSVNPFIPQSFEMQVTDFP
DDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFD
INSIQKIDVECRNFLIDKKIKNENDYEKTIKELQSLQNEKKKPVLYCDIVENLFNSFNDE
IADLTLYKRISRIDENLEESLIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDS
LLYVNDYFKGNY