Protein Info for MMJJ_RS07375 in Methanococcus maripaludis JJ

Annotation: tRNA 2-thiocytidine biosynthesis TtcA family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 324 PF01171: ATP_bind_3" amino acids 77 to 276 (200 residues), 64 bits, see alignment E=1.6e-21 PF03054: tRNA_Me_trans" amino acids 77 to 202 (126 residues), 29.8 bits, see alignment E=4.7e-11

Best Hits

Swiss-Prot: 56% identical to Y485_METJA: Probable sulfurtransferase (MJ0485) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 99% identity to mmp:MMP1353)

Predicted SEED Role

"tRNA(Cytosine32)-2-thiocytidine synthetase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (324 amino acids)

>MMJJ_RS07375 tRNA 2-thiocytidine biosynthesis TtcA family protein (Methanococcus maripaludis JJ)
MIDLKELKKYCNPSYLTIRNDKIIVGNKGLARLSKEKMRKIENDFGIPVVYSRVFEEISE
RMGRFVSKNNIISPKDKILVGLSGGKDSLALLHLLEPYRRKYGVQIYAVTVDLNINGIRP
WTESNKNVEKIAEHCKNLNIPHKIIAHDGNVVEMSKILSENTKGIEYSPCFSCSMVRRHV
LTNYAKNNFESDSNVKIAIGHTLEDNSDTIMANIFKGNIIKALEPIKNFNETDVDFKDFK
LNLKSCCMIRPMLNVSEEKIVKALVECDIEYYHDKDECPYSRHNGNGIRKKSHEVLESIE
EDVPNIREMVISSILNSIEHYKQK