Protein Info for MMJJ_RS07290 in Methanococcus maripaludis JJ

Annotation: translation elongation factor EF-1 subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 TIGR00483: translation elongation factor EF-1, subunit alpha" amino acids 1 to 428 (428 residues), 774.3 bits, see alignment E=2.2e-237 PF00009: GTP_EFTU" amino acids 5 to 214 (210 residues), 184.9 bits, see alignment E=3.7e-58 TIGR00231: small GTP-binding protein domain" amino acids 8 to 167 (160 residues), 43.5 bits, see alignment E=3e-15 PF03144: GTP_EFTU_D2" amino acids 243 to 309 (67 residues), 68.5 bits, see alignment E=1.6e-22 PF14578: GTP_EFTU_D4" amino acids 247 to 309 (63 residues), 29.4 bits, see alignment E=1.9e-10 PF03143: GTP_EFTU_D3" amino acids 316 to 423 (108 residues), 95.6 bits, see alignment E=6.4e-31 PF22594: GTP-eEF1A_C" amino acids 322 to 419 (98 residues), 124.4 bits, see alignment E=6.7e-40

Best Hits

Swiss-Prot: 99% identical to EF1A_METMP: Elongation factor 1-alpha (tuf) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K03231, elongation factor 1-alpha (inferred from 99% identity to mmp:MMP1370)

Predicted SEED Role

"Translation elongation factor 1 alpha subunit" in subsystem Translation elongation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (428 amino acids)

>MMJJ_RS07290 translation elongation factor EF-1 subunit alpha (Methanococcus maripaludis JJ)
MAKEKPILNVAFIGHVDAGKSTTVGRLLLDGGAIDPQLIVRLRKEAEEKGKAGFEFAYVM
DGLKEERERGVTIDVAHKKFPTAKYEVTIVDCPGHRDFIKNMITGASQADAAVLVVNVDD
AKSGIQPQTREHVFLSRTLGITQLAVAINKMDTVNFSEADYNEMKKMLGDQLLKMVGFNP
DNINFIPVASLLGDNVFKKSDKTPWYNGPTLAEVIDGFQPPEKPTTLPLRLPIQDVYSIT
GVGTVPVGRVETGIIKPGDKVVFEPAGAVGEIKTVEMHHEQLPSAEPGDNIGFNVRGVGK
KDIKRGDVLGHTTNPPTVAADFTAQIVVLQHPSVMTVGYTPVFHAHTAQIACTFMELQKK
LNPATGEVLEENPDFLKAGDAAIVKLMPTKPLVMESVKEIPQLGRFAIRDMGMTVAAGMA
IQVTAKNK