Protein Info for MMJJ_RS06705 in Methanococcus maripaludis JJ

Annotation: bifunctional NADP phosphatase/NAD kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00459: Inositol_P
  • amino acids 10 to 278 (269 residues), 99.9 bits, E=2.7e-32
• PF01513: NAD_kinase
  • amino acids 290 to 403 (114 residues), 66.1 bits, E=6e-22
• PF20143: NAD_kinase_C
  • amino acids 429 to 552 (124 residues), 142.4 bits, E=9.7e-46

Best Hits

Swiss-Prot: 99% identical to NPPNK_METMP: Bifunctional NADP phosphatase/NAD kinase (MMP1489) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00858, NAD+ kinase [EC: 2.7.1.23] (inferred from 99% identity to mmp:MMP1489)

Predicted SEED Role

"NAD kinase (EC 2.7.1.23)" in subsystem NAD and NADP cofactor biosynthesis global (EC 2.7.1.23)

MetaCyc Pathways

• NADP biosynthesis (1/1 steps found)
• NAD phosphorylation and transhydrogenation (1/2 steps found)
• NAD phosphorylation and dephosphorylation (1/3 steps found)
• cytosolic NADPH production (yeast) (1/5 steps found)
• mitochondrial NADPH production (yeast) (1/5 steps found)
• NAD(P)/NADPH interconversion (1/6 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (1/8 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.23

Protein Sequence (566 amino acids)

>MMJJ_RS06705 bifunctional NADP phosphatase/NAD kinase (Methanococcus maripaludis JJ)
MDMLEMALNIAKDIEKSVKPLIGWEKSNEVVKIGADGTPTKRIDLIAENVAINSIEKVCS
AILISEEIGFKKIGKNKPEYVIVLDPVDGTYNSLKDIPFYSAAVAIGRIDKFTDNLEELI
NNLKMKDLEVGVVRNIATGDTYYAEKGKGAHFLRKGEKKSISISNSSNLKDSSIGLFAHD
ISIDTLKFIKDRRFRRIRLFGSIALEMCYVAKGALDAFINVNETTRLCDIAAGYVIIKEA
GGIVTDKNGQEVNLDLDVNSKVSVICSNEMLHKKLVGIFGNRWRIKPTNFGIISRIDNEE
SIEVADNVIKYLDSKGIKYELDSSTYDALKNRLTKKCDIISNIEEISHMISIGGDGTVLR
ASKMIEGNEIPMICINMGTVGFLTEFNKDEIFSAIDSIICGNYKVEKRTKLMGFAKLSDG
KQHILSDSLNEVVITTKNPAKMMHFEVYIDGSLVEDVRADGIIVSTPNGSTAYSLSSGGP
IIEPTVEGFVIVPICPFKLSSRPLVVNANSEIKIKLLKKSTYVVIDGNTEFEAKKGDEII
LRKSESNAYFVKGDNFYNKLKKLSLM