Protein Info for MMJJ_RS06505 in Methanococcus maripaludis JJ

Annotation: prephenate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00800: PDT
  • amino acids 2 to 178 (177 residues), 193.1 bits, E=2e-61

Best Hits

Swiss-Prot: 57% identical to PHEA_METJA: Prephenate dehydratase (pheA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K01713, prephenate dehydratase [EC: 4.2.1.51] (inferred from 94% identity to mmp:MMP1528)

Predicted SEED Role

"Prephenate dehydratase (EC 4.2.1.51)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 4.2.1.51)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (17/18 steps found)
• superpathway of L-phenylalanine biosynthesis (9/10 steps found)
• L-phenylalanine biosynthesis I (3/3 steps found)
• L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
• superpathway of chorismate metabolism (25/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.51

Protein Sequence (268 amino acids)

>MMJJ_RS06505 prephenate dehydratase (Methanococcus maripaludis JJ)
MICCLGPRGSYSEKAAVTFSKAINDSEIQFEDSIYNVFKAVETNPEFFGVVPSENSIGGS
VSITQDLLLEFPVKILGEVDISINHCLIGYDIKKVTEVLAHPQALAQCGHYITKNNWNIM
PVDSNAKAAKIVSEKKDEKLAAICGVENAEIYELNVLDENIQDYKNNTTRFFLICNKKKD
FKTDLKPNKVSLVIEINKNMPGAFYEVLGVFKYRNVNLTRIESRPSKKEIGNYVFYIDYE
YYDDNSALLRDLRFWALNVIELGNYFVV