Protein Info for MMJJ_RS06110 in Methanococcus maripaludis JJ

Annotation: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00521: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
  • amino acids 15 to 393 (379 residues), 380.6 bits, E=4.5e-118
• PF02441: Flavoprotein
  • amino acids 18 to 177 (160 residues), 88.3 bits, E=4.4e-29
• PF04127: DFP
  • amino acids 189 to 394 (206 residues), 155.3 bits, E=1.9e-49

Best Hits

Swiss-Prot: 60% identical to COABC_METJA: Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 94% identity to mmp:MMP1606)

MetaCyc: 60% identical to CoaBC monomer (Methanocaldococcus jannaschii)
Phosphopantothenate--cysteine ligase. [EC: 6.3.2.5]; Phosphopantothenoylcysteine decarboxylase. [EC: 6.3.2.5, 4.1.1.36]

Predicted SEED Role

"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• coenzyme A biosynthesis I (bacteria) (4/4 steps found)
• coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)
• superpathway of coenzyme A biosynthesis I (bacteria) (7/9 steps found)
• coenzyme A biosynthesis III (archaea) (3/4 steps found)
• taurine biosynthesis II (1/4 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.36, 6.3.2.5

Use Curated BLAST to search for 4.1.1.36 or 6.3.2.5

Protein Sequence (396 amino acids)

>MMJJ_RS06110 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC (Methanococcus maripaludis JJ)
MHPTKTLHGAKSKLLNGKKLVVAVTSSIAAIEAPKMMRELIRHGAEVYCIMTEETKDIVG
KYSFEFGCGNEVMDKITGKIEHVDLYNKCDGMIVFPATANIISKISLNIADNIVNTTAMM
FLEKKPIIIAPSMHQNMLDTVKPHIKNLSEKNNVFVMGSKMEEEKAKAISIDEVSKLAID
VFSDKKEERKKVLILSGGTAEPIDKVRVITNLSSGKTGVSLAEEFCKNNYNVEVIKGLGK
DVPYYIKSENVITSEEMLKKALELGENADIIISCAAISDYAPETNFEGKLSSDIKTQVIN
LKQTPKVLDELRKKFPQKIIVGYKAEYGTNLDELTEKAKIRLEKYNLDIIVANDLSKHYF
GDDSNEVLIIDKEKALKVSGSKDEISKKIVEMVNNL