Protein Info for MMJJ_RS05720 in Methanococcus maripaludis JJ

Annotation: glutamine--fructose-6-phosphate transaminase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 599 (598 residues), 647.2 bits, E=1.3e-198
• PF13522: GATase_6
  • amino acids 66 to 197 (132 residues), 55.4 bits, E=1e-18
• PF13537: GATase_7
  • amino acids 85 to 203 (119 residues), 56.4 bits, E=4.7e-19
• PF01380: SIS
  • amino acids 290 to 415 (126 residues), 80.4 bits, E=1.6e-26
  • amino acids 458 to 575 (118 residues), 38.4 bits, E=1.6e-13

Best Hits

Swiss-Prot: 98% identical to GLMS_METMP: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 98% identity to mmp:MMP1680)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (4/6 steps found)
• O-antigen building blocks biosynthesis (E. coli) (7/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (3/6 steps found)
• chitin biosynthesis (4/9 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (599 amino acids)

>MMJJ_RS05720 glutamine--fructose-6-phosphate transaminase (isomerizing) (Methanococcus maripaludis JJ)
MCGIIGYIGNERASKILLNGLKRLEYRGYDSCGIATIDDTIKLKKNTGKVLEVSKKENFD
DMNGFIGIGHSRWATHGGITKDNAHPHYDCIEKICIAHNGIISNYKELKELLISKGHIFK
SETDTEVIPHLIEEELKDFKEITEKTYINAIQNTIKKLNGTYALLILNQDFPEMLVGVRN
ESPLILGIKKDECFIGSDISAFLEYTKLAMPLNDRDIVILRKENDKIDIEVLNDGKQVQR
DKIELQWDMESAEKEGYEHFMLKEIMEEPVILKNSMKISKLEIENLGKEIEKCDKIYITA
MGTSLHAAMVAEYWFSGLNKLVIPIDSSEFLTKGIVDEKTLVIAITQSGETYDTMKAVKY
AKEKGAKTATIVNVLGSTATREADITIMMGSGLEIAVCATKTFMSQLVILYRLFIEYGKI
IGKNMDIFEKELLNIPNYVSKVLDEKENISKIAEELTAKNYLFISKGINLANALEGALKF
KEITYLHAEGMSSGFLKHGTISLIDENMDTVALIPPSKSELLSPVLSNVEEIKARNGKII
GISPVEDNLKYSIKVPDVIEEVSPFVYATACQLLAYYKAVDLKRDVDKPRGLAKSVTVE