Protein Info for MMJJ_RS05395 in Methanococcus maripaludis JJ

Annotation: argininosuccinate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00838: argininosuccinate lyase
  • amino acids 4 to 458 (455 residues), 610.2 bits, E=1.3e-187
• PF00206: Lyase_1
  • amino acids 11 to 297 (287 residues), 212 bits, E=1.5e-66
• PF14698: ASL_C2
  • amino acids 364 to 433 (70 residues), 59.9 bits, E=2.7e-20

Best Hits

Swiss-Prot: 99% identical to ARLY_METMP: Argininosuccinate lyase (argH) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01755, argininosuccinate lyase [EC: 4.3.2.1] (inferred from 99% identity to mmp:MMP0013)

Predicted SEED Role

"Argininosuccinate lyase (EC 4.3.2.1)" in subsystem Arginine Biosynthesis extended (EC 4.3.2.1)

MetaCyc Pathways

• L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• superpathway of arginine and polyamine biosynthesis (13/17 steps found)
• nitric oxide biosynthesis II (mammals) (2/3 steps found)
• urea cycle (3/5 steps found)
• canavanine biosynthesis (2/4 steps found)
• L-arginine biosynthesis IV (archaea) (4/9 steps found)
• superpathway of L-citrulline metabolism (6/12 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.2.1

Protein Sequence (481 amino acids)

>MMJJ_RS05395 argininosuccinate lyase (Methanococcus maripaludis JJ)
MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLVEQNVISEENGKKII
AELKKIAKKGMENLDLDPSLDDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLS
LRKKVLEIIGHLITMEKNMLAVSNAHKDTLTVGYTHLQQAQPVTFGHQILSHVSAIERDI
SRFFDTYNRINISPLGCGAMATTGFNLNRKRTKDLLGFYGIIENSMDGVSSRDFIVETMA
NISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLN
GELVTVLTIMKALPNTYNRDLQEISPHLWKSVYTLIDSIQMVDGMISTVKVNKERMKENA
EKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEKVEIKEIISEVLEKNNLSLSQ
EKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNEKISTHKVKLDEKISEIKTAEKNLL
E