Protein Info for MMJJ_RS04730 in Methanococcus maripaludis JJ

Annotation: tyrosine decarboxylase MfnA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03812: tyrosine decarboxylase MnfA
  • amino acids 3 to 379 (377 residues), 561.8 bits, E=3.2e-173
• PF00155: Aminotran_1_2
  • amino acids 57 to 377 (321 residues), 30.5 bits, E=3.3e-11
• PF00282: Pyridoxal_deC
  • amino acids 60 to 329 (270 residues), 94.6 bits, E=8.2e-31
• PF00266: Aminotran_5
  • amino acids 82 to 196 (115 residues), 22.2 bits, E=9.8e-09

Best Hits

Swiss-Prot: 97% identical to MFNA_METMP: Probable L-tyrosine/L-aspartate decarboxylase (mfnA) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01592, tyrosine decarboxylase [EC: 4.1.1.25] (inferred from 97% identity to mmp:MMP0131)

MetaCyc: 58% identical to L-tyrosine decarboxylase subunit (Methanocaldococcus jannaschii)
Tyrosine decarboxylase. [EC: 4.1.1.25, 4.1.1.28]; Aspartate 1-decarboxylase. [EC: 4.1.1.25, 4.1.1.28, 4.1.1.11]

Predicted SEED Role

"L-tyrosine decarboxylase (EC 4.1.1.25)" (EC 4.1.1.25)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (7/9 steps found)
• β-alanine biosynthesis III (1/1 steps found)
• octopamine biosynthesis (1/2 steps found)
• methanofuran biosynthesis (4/8 steps found)
• salidroside biosynthesis (1/4 steps found)
• hydroxycinnamic acid tyramine amides biosynthesis (1/5 steps found)
• (S)-reticuline biosynthesis II (1/7 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (2/9 steps found)
• (S)-reticuline biosynthesis I (2/11 steps found)
• indole-3-acetate biosynthesis II (2/12 steps found)
• Amaryllidacea alkaloids biosynthesis (1/26 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Alkaloid biosynthesis I
• Biosynthesis of alkaloids derived from shikimate pathway
• Histidine metabolism
• Indole and ipecac alkaloid biosynthesis
• Pantothenate and CoA biosynthesis
• Phenylalanine metabolism
• Tryptophan metabolism
• Tyrosine metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.11 or 4.1.1.25 or 4.1.1.28

Protein Sequence (384 amino acids)

>MMJJ_RS04730 tyrosine decarboxylase MfnA (Methanococcus maripaludis JJ)
MDEQDILNELREYRNQDLKYEEGYILGSMCTKPHPMARKISEMFFETNLGDPGLFKGTSK
LEKEVVSMIGGILHNNNVFGYIISGGTEANLTAMRAFKNISKSKGKPQNIIIPETAHFSF
DKAKDMMDLNVVRPPLTKYFTMDVKFIRDYIEDSKNEVSGIVGIAGCTELGSIDNICELS
KIAVENDILLHVDAAFGGFVIPFLDDKYKLDGYNYDFDFSLNGVSSITIDPHKMGLAPIS
AGGILFRDNTFKKYLDVDAPYLTEKQQATIIGTRSGVGVASTWGIMKLLGIDGYETLVNE
SMEKTTHLVKKAREYGFETAIDPVMNIVALKDENKHETCMKLREENWYVSVCRCVDALRI
VVMPHLEIEHIDGFLESLSNTKKY