Protein Info for MMJJ_RS04700 in Methanococcus maripaludis JJ

Annotation: deoxyhypusine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00321: deoxyhypusine synthase
  • amino acids 20 to 335 (316 residues), 418.1 bits, E=1.1e-129
• PF01916: DS
  • amino acids 35 to 331 (297 residues), 382.5 bits, E=6.5e-119

Best Hits

Swiss-Prot: 88% identical to DHYS_METVS: Probable deoxyhypusine synthase (dys) from Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)

KEGG orthology group: K00809, deoxyhypusine synthase [EC: 2.5.1.46] (inferred from 98% identity to mmq:MmarC5_1539)

Predicted SEED Role

"Deoxyhypusine synthase (EC 2.5.1.46)" (EC 2.5.1.46)

MetaCyc Pathways

• hypusine biosynthesis (4/5 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.46

Protein Sequence (335 amino acids)

>MMJJ_RS04700 deoxyhypusine synthase (Methanococcus maripaludis JJ)
MSDPKNVVFKESEDLNGVFIEGPDFDETIDLKDVLTDYYEKIGFQATHLGKAVKIWKQIE
EVRKNEEVVVFMGYTSNMVSSGLREIISYLVKHKKVDVLVTTAGGIEEDFIKCIKPFVLG
EWDMAGSDLREKGINRIGNVYVPNDRYIEFETYMTKFFETLLKKQQDENKIISASEFCFE
LGRFMDENLGAEKEKSIIYWAYVNKIPIFCPAITDGSIGDMLYFFKKNEKGTDLKIDVAS
DIVKLNDMAIDANKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAVPWDGSLSGAPP
EEGVSWGKIQEKADFVEIWADATIVFPMLVYGVFK