Protein Info for MMJJ_RS04640 in Methanococcus maripaludis JJ

Annotation: TIGR01177 family methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 TIGR01177: putative methyltransferase, TIGR01177 family" amino acids 10 to 347 (338 residues), 319.6 bits, see alignment E=1.3e-99 PF02926: THUMP" amino acids 99 to 159 (61 residues), 34.4 bits, see alignment E=9.7e-12 PF01170: UPF0020" amino acids 177 to 324 (148 residues), 103.7 bits, see alignment E=4.4e-33 PF01555: N6_N4_Mtase" amino acids 179 to 240 (62 residues), 30.7 bits, see alignment E=1.2e-10 PF02384: N6_Mtase" amino acids 191 to 292 (102 residues), 30.8 bits, see alignment E=7.8e-11 PF13847: Methyltransf_31" amino acids 203 to 321 (119 residues), 31 bits, see alignment E=7.5e-11 PF03602: Cons_hypoth95" amino acids 204 to 339 (136 residues), 27.6 bits, see alignment E=8.9e-10 PF09445: Methyltransf_15" amino acids 206 to 298 (93 residues), 35.7 bits, see alignment E=2.6e-12

Best Hits

Swiss-Prot: 49% identical to TMG10_METJA: tRNA (guanine(10)-N2)-dimethyltransferase (trmG10) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07446, putative methyltransferase (inferred from 98% identity to mmp:MMP0149)

Predicted SEED Role

"tRNA-(G10-N2) methyltransferase; tRNA-(G10-N2) dimethyltransferase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (350 amino acids)

>MMJJ_RS04640 TIGR01177 family methyltransferase (Methanococcus maripaludis JJ)
MNLKNTKAGFLLSAEHEKLPVAELNALIDIFSLEGNLNCFKNYVILESSISEEIIKKMVK
RGGYTNEGHVIFSESPIINQNVDETLENFFKSSETLDFPVERDETFAVRVLKMEKESPFN
SMEIERKLGGIIKKKTSAQVSLKNPSKTVKVVISNDTMYTGIVIEKRDVEYFQNNRPHLR
AYFHPGCIMPKLARCLVNLSRVKEGEIVLDPFCGTGGFLIEAGFLGCRLIGSDIDEQMVN
GALLNLNTYDLSKQVISIKQNDAKNVSKYLEDLKIEKIDGIVTDPPYGISTSKKGDMLEI
FEKIVDVLKDNDYLVFAAPNRMELDLNLVEFYEMRVHKSLTRYIHVYRKN