Protein Info for MMJJ_RS04555 in Methanococcus maripaludis JJ

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 50 to 74 (25 residues), see Phobius details amino acids 94 to 123 (30 residues), see Phobius details amino acids 136 to 157 (22 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 194 to 215 (22 residues), see Phobius details amino acids 238 to 264 (27 residues), see Phobius details amino acids 284 to 307 (24 residues), see Phobius details amino acids 319 to 338 (20 residues), see Phobius details amino acids 359 to 382 (24 residues), see Phobius details amino acids 393 to 415 (23 residues), see Phobius details amino acids 421 to 443 (23 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 24 to 423 (400 residues), 268.4 bits, see alignment E=5e-84 PF01554: MatE" amino acids 24 to 183 (160 residues), 121.4 bits, see alignment E=3.1e-39 amino acids 245 to 410 (166 residues), 93 bits, see alignment E=1.6e-30 PF14667: Polysacc_synt_C" amino acids 139 to 255 (117 residues), 35.8 bits, see alignment E=8.4e-13

Best Hits

Swiss-Prot: 43% identical to Y709_METJA: Uncharacterized transporter MJ0709 (MJ0709) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 98% identity to mmp:MMP0166)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (460 amino acids)

>MMJJ_RS04555 MATE family efflux transporter (Methanococcus maripaludis JJ)
MKTTKGVQNLLGDPKKAIVKISLPMVIAMSFQSLYNIIDAIWVAGLGSDALAAIGLFFPF
MFALIAISNGVGIGGSSAISRRIGQKNKDAADNIAVHSIVLGIILGILLTGVIPFLGTIF
SLIGASGNTVTMAVEYSTILFGGAVALLFTNIANAILRGEGDTKRAMYAIILGSVLNIVL
DPIFIYVLNMGVAGAAWATLLSLVITGILFVYWLFIKKDTFLKISFEKFKLDINIIKEIF
SIGLPASISHLTMAFSMFLLTAIVAKAGGNDGIAVFSTGWRIVSMGTIPLVGLATGVTVV
TGAAYGSANPEKLEISYKYALKMGILVETIIAALILIFENQITYLFTYSENSVHILEGLL
VFLKYMFLFYPTLPLGMLTAAMFQGVSKGNNSLFISLLRTIILQIPMAYTFGIIFNQGLT
GVWFGMILGHVIAVSIAYLLGIYTIRQFKATLTPETVKFK