Protein Info for MMJJ_RS04130 in Methanococcus maripaludis JJ

Annotation: anaerobic ribonucleoside-triphosphate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 770 PF03477: ATP-cone" amino acids 12 to 83 (72 residues), 36 bits, see alignment E=8.4e-13 amino acids 93 to 163 (71 residues), 40.2 bits, see alignment E=4.2e-14 TIGR02487: anaerobic ribonucleoside-triphosphate reductase" amino acids 187 to 763 (577 residues), 705.2 bits, see alignment E=3.4e-216 PF13597: NRDD" amino acids 188 to 762 (575 residues), 574.9 bits, see alignment E=2.1e-176

Best Hits

KEGG orthology group: K00527, ribonucleoside-triphosphate reductase [EC: 1.17.4.2] (inferred from 100% identity to mmp:MMP0227)

Predicted SEED Role

"Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)" in subsystem Ribonucleotide reduction (EC 1.17.4.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (770 amino acids)

>MMJJ_RS04130 anaerobic ribonucleoside-triphosphate reductase (Methanococcus maripaludis JJ)
MISNSKYVDFKINIVKRSGNEETFNINKLVKSLLNSGVDYENIDEILSEIYGKVYNGMST
DDLKSILYTTLKEYDKKTGKSYSKKYMSENCLKIRTSEKEFEPFNKEKIVKALIQEAGAD
LKTAERIATEVESEVKNLNVTYLTAPMIREIVNTKLIEHGLEEFRHKHTRLGIPVYDIVK
LIERGSKDNANLMHNPESIHKWVADETMKQFALLNVFPKYIADSHMRGDIHLHDLEYAAV
RTVCCQHDLRNFFKYGLKVDGTGRHTSVSKPAKHPDVALQHAAKVLSAAQCEMSGGQSID
EFNIWIAPYMRGLEYSEVRQLMQLFIYEMNQIYAARGGQVVFSSINLELEVPEYLKGKDA
IKAGQVVGAYEEYDYEVKMIAEALVDVLMDGDAYGKPFLFPNVIFKLRENAFKDENKDLL
VKIHELSAKWGLPYFINMFADYQHGNTNAMGCRTRLSGEWGNSIEESSLRTGNMQWYTIN
LPRIAYEADGDDGRLFEILDEKLAIAKQALEIKHEISKRRLYHDNVLPFLTQEFDGEQYY
RYDSTTKTFGFVGLNELLKYHVGSELHESPEALAFGVKVISHIRKYADDLKKETGLRWTV
TQTPAESTAGRFAKFDHKYYPEETKSVVNGNLNDLSSIYYTNSSHVRVNADVTLGEKVGI
EEKFHELCNGGHIGHFWNAEAYADPEVLMDITKKMTKTDIGFWTYTKNLSICEKCSLAMS
GLKDNCTGCGSESVEKFSRITGYLQNVSNWNKAKQQELLDRKSTLPGRRI