Protein Info for MMJJ_RS03850 in Methanococcus maripaludis JJ

Annotation: nucleoside-diphosphate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00334: NDK
  • amino acids 8 to 137 (130 residues), 177.9 bits, E=4.7e-57

Best Hits

Swiss-Prot: 97% identical to NDK_METMP: Nucleoside diphosphate kinase (ndk) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00940, nucleoside-diphosphate kinase [EC: 2.7.4.6] (inferred from 96% identity to mmp:MMP0283)

MetaCyc: 49% identical to nucleoside diphosphate kinase B (Homo sapiens)
Nucleoside-diphosphate kinase. [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]; 2.7.4.6 [EC: 2.7.4.6]

Predicted SEED Role

"Nucleoside diphosphate kinase (EC 2.7.4.6)" in subsystem Purine conversions (EC 2.7.4.6)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (15/18 steps found)
• superpathway of histidine, purine, and pyrimidine biosynthesis (35/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (17/21 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• CMP phosphorylation (2/2 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (7/9 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (4/5 steps found)
• guanosine ribonucleotides de novo biosynthesis (3/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (5/7 steps found)
• superpathway of purine nucleotide salvage (10/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (4/6 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis I (1/2 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis I (1/2 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (6/9 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (5/8 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (4/7 steps found)
• superpathway of pyrimidine ribonucleosides salvage (6/10 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (5/9 steps found)
• dZTP biosynthesis (2/5 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (17/26 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (4/8 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis II (1/4 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis II (1/4 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (8/14 steps found)
• purine deoxyribonucleosides salvage (2/6 steps found)
• ppGpp metabolism (1/6 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.6

Protein Sequence (139 amino acids)

>MMJJ_RS03850 nucleoside-diphosphate kinase (Methanococcus maripaludis JJ)
MVCENEVERTFVALKPDTVERKLVGRVIQRFEDRGFEIVEMRMLTLTGKMAEEYYGEHKG
KEFYEILIKFMTSGRIVAMVIKGERAISTVRKMLGNTCPCDAEPGTIRGDFGLYTPANII
HASDSLESAEREIDLFFGI