Protein Info for MMJJ_RS03290 in Methanococcus maripaludis JJ

Annotation: amidohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 PF01979: Amidohydro_1" amino acids 62 to 397 (336 residues), 188.5 bits, see alignment E=1e-59

Best Hits

Swiss-Prot: 42% identical to MTAD_DICTD: 5-methylthioadenosine/S-adenosylhomocysteine deaminase (mtaD) from Dictyoglomus turgidum (strain Z-1310 / DSM 6724)

KEGG orthology group: None (inferred from 96% identity to mmp:MMP0378)

Predicted SEED Role

"S-adenosylhomocysteine deaminase (EC 3.5.4.28); Methylthioadenosine deaminase" (EC 3.5.4.28)

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.28

Use Curated BLAST to search for 3.5.4.28

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (426 amino acids)

>MMJJ_RS03290 amidohydrolase (Methanococcus maripaludis JJ)
MILIKNASFYIDNNLNVHENCDILIEKVENETKLTSGKNLIEKLNLNQNDLKIISGEKKC
AMTGLYNAHTHIPMTLLRGIADDMILQNWLNQKIWPNEAKLTKNDVYYGSLLGCLEMLRF
GVTSFNEMYFFSEEILKATKEIGLNAQVSYPIIDFGTPEEQSIDKLLTSAESFVKNNAGE
KNIKVGIAPHAPYTCSEETYQKCSEISNDYNVNMHTHVSETRYEVVELENKIGMRPVEYL
EKIGVLNEKLHAAHCVWITKDEAKKLAKNNVKVLHCPTSNMKLASGGVMPLFELLEYGAD
ISVGTDGPASNNNLDIFKEMKMTSLLHKAHRWDPTVAGIDTVLKMGINSKSIGIKNNDII
LIDLDSAHLRPFNNIKSNIVYSAFGNDVDTVIVGGNILLENKKYKFSETFISNIYKNIQK
ITEKFE