Protein Info for MMJJ_RS02745 in Methanococcus maripaludis JJ

Annotation: type I restriction endonuclease subunit R

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1032 PF04313: HSDR_N" amino acids 6 to 209 (204 residues), 166.4 bits, see alignment E=1.9e-52 TIGR00348: type I site-specific deoxyribonuclease, HsdR family" amino acids 7 to 701 (695 residues), 636 bits, see alignment E=4.1e-195 PF18766: SWI2_SNF2" amino acids 268 to 516 (249 residues), 266.8 bits, see alignment E=4.1e-83 PF04851: ResIII" amino acids 275 to 449 (175 residues), 70.2 bits, see alignment E=5e-23 PF22679: T1R_D3-like" amino acids 616 to 684 (69 residues), 69.9 bits, see alignment 8.8e-23 PF11867: T1RH-like_C" amino acids 701 to 1027 (327 residues), 422.6 bits, see alignment E=3.1e-130

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 99% identity to mmx:MmarC6_0040)

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1032 amino acids)

>MMJJ_RS02745 type I restriction endonuclease subunit R (Methanococcus maripaludis JJ)
MSNLCEDTIEQGTLELLKSIGYEIISGPEIAPDGTSPERKDYSEVVLVSRLRNAISRINP
KVPEVAREDALRKVLRLENPNLLMNNEKFHEFIFKGIDVEYPIDGRVKGDKVYLLDKNPL
KNEFVAVNQFTIIQNNKNRRPDIVIFVNGLPLSVIELKNPTKEDATIWSAYNQIQTYKSE
ISELFKYNELILISDGTESRIGTLSSNKEWFLPWKSIDGTSEINNGVSQLKISILGMFDK
TRFIDIIKNFIVFKKDGKDIIKVIAGYHQYFAANRAIEKTIEAVSGNRRCGVVWHTQGSG
KSLTMAFYAGKLAITPELRNPTIVVVTDRNDLDDQLFGTFASCIDVLKQTPVQAKNAEDL
KEQLQVVSGGVIFTTMQKFSVDELNAKYPMLSDRENIIVMADEAHRSQYGLKARSVEKNG
EVGITYGFAKYLRDALPNASFIGFTGTPIDFEDKSTRSIFGEYIDIYDVRRAVADGRTVK
IYYESRVAKIGIENDVLAKLDAEFEEVTEFEENYKKEKLKGKWAQLEAIVGSSDRISKVA
QDIVNHFEKREETLSGKAIVVCMSRRICVDLYDEIIRLRPDWHNDDDKLGVLKVIMTGSA
ADGTEWQKHIRSKGKRKELAEHFKNPESEFKIAIVRDMWLTGFDVPCLHTLYIDKPMKGH
GLMQAIARVNRVFRDKPGGLVVDYIGIAQDLKYALMNYTSSGGTGKPTYDIEDAVNLMKS
KYEAMKDFFYGHDYSKFFNGTNIEKMDVIPETLEFILTQPDGKKRFVKLALELIKSYALS
LPHEEAVKIREEVAFFTGVKAALYKNTEISGKPEDELNSAIKQIVSGAVRTDGIIDVFGE
AGLEKPDISILSEQFLEDVKNMKYKNLALETLKKILNDEIRAKFKNNLLQEKKFSEMIEN
AIKRYHNKAIDSAAVIQELIAIAKEIENAKRRGEELHLTEEELAFYDALSDNDSAKEILG
TEILTEIARELTETLRNSVSIDWEVRETVRATLRVKIKRLLRKYGYPPDKQQIAADLVLK
QAETISKEWIKT