Protein Info for MMJJ_RS01400 in Methanococcus maripaludis JJ

Annotation: leucine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 955 transmembrane" amino acids 82 to 99 (18 residues), see Phobius details TIGR00395: leucine--tRNA ligase" amino acids 19 to 955 (937 residues), 1261.3 bits, see alignment E=0 PF00133: tRNA-synt_1" amino acids 23 to 683 (661 residues), 135.4 bits, see alignment E=4.7e-43 PF09334: tRNA-synt_1g" amino acids 45 to 118 (74 residues), 36.5 bits, see alignment 5e-13 amino acids 607 to 691 (85 residues), 38.1 bits, see alignment E=1.6e-13 PF13603: tRNA-synt_1_2" amino acids 226 to 350 (125 residues), 39.7 bits, see alignment E=7.8e-14 PF08264: Anticodon_1" amino acids 722 to 850 (129 residues), 89.6 bits, see alignment E=3.9e-29

Best Hits

Swiss-Prot: 98% identical to SYL_METMP: Leucine--tRNA ligase (leuS) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01869, leucyl-tRNA synthetase [EC: 6.1.1.4] (inferred from 98% identity to mmp:MMP0697)

Predicted SEED Role

"Leucyl-tRNA synthetase (EC 6.1.1.4)" (EC 6.1.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (955 amino acids)

>MMJJ_RS01400 leucine--tRNA ligase (Methanococcus maripaludis JJ)
MDQKEVIGETGHKSVDLIKIMDKWQKKWTEAKIFEAEHDSRDKFFITAAFPYLNGVLHAG
HLRTFTIPETIARYQRMKNKNVLWTFGFHVTGTPILGLANQIKERKKDIIWAYNNLHNIP
MDELLKLNTPEAIVECFSKKATEAFKRMGFSLDWRRNFKTDDKVFSKFIEWQFYNLKEMG
HITKGSHPVRYCPKCENPVEDHDLLHGEESTTVEYSLIKFTSNFDGKEIIMPMATLRPET
VFGVTNAWVNPNEIYVMAEVHDEIQKLDSEDVDLKYNGIWVIGKECADKLKEQDRKIEIL
KEIKGSELLGLKIKNPVTKKEVPLLPADFVEMGIGTGCVMSVPAHAPYDYVALRDLGKVE
EVGLIPLIEIEGYDKYPAKEIVEKLGVKDQNDEELLEQATSKIYKDEFHKGKLNENCGEY
AGISVKDIKEKLTKDYINSNIAEIMYEFSEQKVVCRCGEKCIIKTVKGQWFINYSDENWK
KLAHECIDNMNFAPEGIRQEFHNKVDWMKDKACARKKGLGTILPFDENWIIESLSDSTIY
MAYYTIARFINEGLTPEQLIPELFDYVYLGKGNVDEIAKNSKIPTETIEEMRKEFLYYYP
LDWRCSAKDLIPNHLTFMIFNHVALFGREHWPRGIEINGYVTIEGKKLSKSKGPVLPVSE
VAENFGADVARFYITTCAELPQDADVKFKEMEKARDNLIKLYELAVSVMEEEKTEKELSL
IDKWLLHKTYSSIKGAETAYEEFQLRKIGLMFYELINDLRWYKRRGGENNNVLKEVVEIW
TKLLSPVTPHLCEEIWEKLGYAGFISQEMYPLIKPELINEDLELGEEFIKSAMEDIRNIK
GVAKINPEKMYLYTADDWKYDLLEFMNENAEKNVKALIPLVMKEDKFKRHGKEVMKLINE
IMKIGVKKAIAEVEILENAKTFIESEFDCKVIVNGEDVKGKKKFAIPYKPAIYME