Protein Info for MMJJ_RS01215 in Methanococcus maripaludis JJ

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 55 to 80 (26 residues), see Phobius details amino acids 93 to 116 (24 residues), see Phobius details amino acids 136 to 156 (21 residues), see Phobius details amino acids 168 to 187 (20 residues), see Phobius details amino acids 193 to 212 (20 residues), see Phobius details amino acids 243 to 262 (20 residues), see Phobius details amino acids 273 to 292 (20 residues), see Phobius details amino acids 320 to 342 (23 residues), see Phobius details amino acids 362 to 382 (21 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 417 to 437 (21 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 22 to 418 (397 residues), 167.4 bits, see alignment E=2.4e-53 PF01554: MatE" amino acids 22 to 183 (162 residues), 79.3 bits, see alignment E=2.7e-26 amino acids 249 to 402 (154 residues), 55.6 bits, see alignment E=5.4e-19 PF14667: Polysacc_synt_C" amino acids 138 to 289 (152 residues), 30.9 bits, see alignment E=2.8e-11

Best Hits

KEGG orthology group: None (inferred from 97% identity to mmp:MMP0733)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>MMJJ_RS01215 MATE family efflux transporter (Methanococcus maripaludis JJ)
MKQVKKLENEKINNLMIRYVIPSIAGTVIIGIYGIIDGIFIGRTVGAEGLAGVTFSFPVL
IAISSIGVMIGAGSSAIISISLGKKDYKKASCILKTALTYIILISLIITCFGYLLIDPVI
SFMNLSKNLEIYVAGYSKIIILGAIAQIFAISLDPILRNDGFPKKSMIILALMSIFNIIL
DYILIVIFNFGVIGAAAATVLAQGLGSILYLKHFLSGKSNVKIGKNSPFLEFSTIKRIAK
TGFSPFIMELAFGILMIVHNIQFMRYGSPLDVSAYGIVIYITSFLYMVYLGISEGVQPLI
SYNHGAKKFNRVFEILKKAVFVNAILGICSFLTILKFPNLLIKIFNPHDTNLITTTTIGL
EIHNFAILIMGVSMVLMMYFLATEQPKIAGFLSLGRTLIFILPAIILFPIYLGIKGIWWS
TVFSEYLSFIITIYFITKEFKKIKYEKLNVKK