Protein Info for MMJJ_RS00615 in Methanococcus maripaludis JJ

Annotation: nucleoside deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14437: MafB19-deam
  • amino acids 3 to 131 (129 residues), 76.7 bits, E=1.6e-25
• PF00383: dCMP_cyt_deam_1
  • amino acids 3 to 97 (95 residues), 88.1 bits, E=3.1e-29

Best Hits

Swiss-Prot: 55% identical to FCA1_CANAX: Cytosine deaminase (FCA1) from Candida albicans

KEGG orthology group: K01485, cytosine deaminase [EC: 3.5.4.1] (inferred from 94% identity to mmp:MMP0869)

MetaCyc: 51% identical to cytosine deaminase (Saccharomyces cerevisiae)
Cytosine deaminase. [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]

Predicted SEED Role

"Cytosine deaminase (EC 3.5.4.1)" (EC 3.5.4.1)

MetaCyc Pathways

• pyrimidine nucleobases salvage II (2/2 steps found)
• pyrimidine ribonucleosides salvage III (1/2 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.1

Protein Sequence (145 amino acids)

>MMJJ_RS00615 nucleoside deaminase (Methanococcus maripaludis JJ)
MTDFMDEAIKEANLGLKEGGIPIGAVLVYENKIIGRGHNRRVQNNSSILHAEMDALENAG
RLTSNIYKNCELYTTLSPCIMCSGAVLLYKIKKVVIGENKTFLGAEDLLMNNGVAVEVLN
DERCVKMMEEFIGNNPKLWNEDIGE