Protein Info for MMJJ_RS00595 in Methanococcus maripaludis JJ

Annotation: tetratricopeptide repeat protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 571 PF13181: TPR_8" amino acids 139 to 169 (31 residues), 27.5 bits, see alignment (E = 1.6e-09) amino acids 419 to 444 (26 residues), 17.8 bits, see alignment (E = 2.1e-06) amino acids 447 to 478 (32 residues), 16.2 bits, see alignment (E = 6.8e-06) amino acids 481 to 513 (33 residues), 26.4 bits, see alignment (E = 3.6e-09) PF00515: TPR_1" amino acids 141 to 170 (30 residues), 35.2 bits, see alignment (E = 5.3e-12) amino acids 481 to 513 (33 residues), 39 bits, see alignment (E = 3.3e-13) PF07719: TPR_2" amino acids 141 to 169 (29 residues), 29.4 bits, see alignment (E = 3.6e-10) amino acids 481 to 513 (33 residues), 30.6 bits, see alignment (E = 1.5e-10) PF13374: TPR_10" amino acids 142 to 166 (25 residues), 16.4 bits, see alignment (E = 5.3e-06) amino acids 484 to 509 (26 residues), 19 bits, see alignment (E = 7.9e-07) PF13414: TPR_11" amino acids 144 to 176 (33 residues), 31.8 bits, see alignment (E = 6.7e-11) amino acids 492 to 526 (35 residues), 27.5 bits, see alignment (E = 1.4e-09) PF13432: TPR_16" amino acids 418 to 478 (61 residues), 26.7 bits, see alignment E=4.6e-09 amino acids 490 to 543 (54 residues), 31.7 bits, see alignment 1.3e-10 PF10373: EST1_DNA_bind" amino acids 435 to 530 (96 residues), 25.1 bits, see alignment E=8.8e-09 PF13431: TPR_17" amino acids 435 to 466 (32 residues), 22.6 bits, see alignment (E = 6.2e-08) amino acids 469 to 501 (33 residues), 25.1 bits, see alignment (E = 9.5e-09) amino acids 503 to 534 (32 residues), 29.3 bits, see alignment (E = 4.3e-10) PF13424: TPR_12" amino acids 482 to 545 (64 residues), 34.4 bits, see alignment E=1.4e-11 PF13176: TPR_7" amino acids 482 to 512 (31 residues), 17 bits, see alignment (E = 3.6e-06) PF14559: TPR_19" amino acids 491 to 551 (61 residues), 41.7 bits, see alignment E=8.4e-14

Best Hits

KEGG orthology group: None (inferred from 92% identity to mmp:MMP0873)

Predicted SEED Role

"TPR domain protein, putative component of TonB system" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (571 amino acids)

>MMJJ_RS00595 tetratricopeptide repeat protein (Methanococcus maripaludis JJ)
MADYNNAVVFYDTSGIEYSKQIKKTLERGFERECFLINLDNRENTLSRLNLAMKTSKYVI
FLFSSMYSNENMLDEAKTAYNSDKYIISLKLDDPELKKQISIHQPEFEDNYSLSKKVNDE
VEKLKKMEKKGTDFVESQISFNMGNIYFNFGKYAEAIRCYKKAVKIIPDFVDALHNFNSL
SNMNLFDMGEETKKPVLYKDVKIDELVPDIFSKTVQEESEEPQKYSELEPEELEDLILEG
EIGENFEETESEDEVTEKIDDKLPEIDESEDNSETQPEDELNENFEEDIKEDIKCETFEV
TDPEEKNEISDENLEVSIVEPEFEEESIFELEKETEQPEIEENLESVFEVPEELVEDVEI
LDAIEEDIENELENSEGLIEEKLETLDELLDKSELESELVEEYTYEIDNKEFLEILSFAN
TLYESGDFEAAKTEYKKAIALNPGHSEAHNHYGCLLEYLEKYGEAEIEFKKAIALDGSNS
KAHNNLATFLAKSEKYDEAEEHYKKAIEIDPDYWAAIYNLAAMYAALKRYDEAVAQVKSM
VKIFRSDGNIKEVLELKKLIKHLKKLKIQKS