Protein Info for MMJJ_RS00360 in Methanococcus maripaludis JJ

Annotation: adenosylhomocysteinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05221: AdoHcyase
  • amino acids 3 to 133 (131 residues), 120.1 bits, E=2.2e-38
  • amino acids 137 to 414 (278 residues), 93.1 bits, E=3.8e-30
• TIGR00936: adenosylhomocysteinase
  • amino acids 3 to 415 (413 residues), 664.2 bits, E=3.6e-204
• PF00670: AdoHcyase_NAD
  • amino acids 183 to 343 (161 residues), 179.8 bits, E=9.3e-57
• PF02826: 2-Hacid_dh_C
  • amino acids 202 to 293 (92 residues), 33.8 bits, E=4.6e-12
• PF07991: IlvN
  • amino acids 203 to 267 (65 residues), 23.9 bits, E=5.4e-09

Best Hits

Swiss-Prot: 99% identical to SIHH_METMP: S-inosyl-L-homocysteine hydrolase (ahcY) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01251, adenosylhomocysteinase [EC: 3.3.1.1] (inferred from 99% identity to mmp:MMP0920)

MetaCyc: 47% identical to S-adenosylhomocysteine hydrolase subunit (Rattus norvegicus)
ADENOSYLHOMOCYSTEINASE-RXN [EC: 3.13.2.1]

Predicted SEED Role

"Adenosylhomocysteinase (EC 3.3.1.1)" in subsystem Methionine Biosynthesis or Methionine Degradation (EC 3.3.1.1)

MetaCyc Pathways

• S-adenosyl-L-methionine salvage II (3/3 steps found)
• L-methionine degradation I (to L-homocysteine) (2/3 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (2/5 steps found)
• superpathway of L-methionine salvage and degradation (3/16 steps found)

KEGG Metabolic Maps

• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.13.2.1 or 3.3.1.1

Protein Sequence (415 amino acids)

>MMJJ_RS00360 adenosylhomocysteinase (Methanococcus maripaludis JJ)
MSNVKDMSLAPSGHLKMEWAKRHMPVLCRIAEEFKNDKPFEGLTIGMALHLEAKTAILAE
TLLKGGAKIVITGCNPLSTQDDVAAACVEKGMEVYAWRGETNEEYYENLNKVLDSNPDIV
IDDGADLIFLIHTERTELIGKIMGGCEETTTGIIRLKSMAEEGALKFPVVNVNDAYTKHL
FDNRYGTGQSAMDGIIRTTNLLIAGKNVVVGGYGWCGRGVASRAAGHGANVIITEVNPIR
ALEAKMDGFTVLKMEEAAKIGDIFVTTTGCKDILRMEHFLLMKDGAVLSNAGHFDNEINK
NDLKELSKSVKEVRFNIEEYDLGNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALSA
KFIKENKGKLENEVYEIPYEQDFKIALLKLHSMGADIDELSPEQRKYLSDWKEGT