Protein Info for MMJJ_RS00325 in Methanococcus maripaludis JJ

Annotation: chemotaxis protein CheA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 920 PF01627: Hpt" amino acids 7 to 103 (97 residues), 66.9 bits, see alignment E=3.9e-22 PF07194: P2" amino acids 324 to 401 (78 residues), 43.4 bits, see alignment E=7.5e-15 amino acids 430 to 508 (79 residues), 78.6 bits, see alignment E=7.6e-26 PF02895: H-kinase_dim" amino acids 543 to 602 (60 residues), 64.1 bits, see alignment 3.2e-21 PF02518: HATPase_c" amino acids 651 to 790 (140 residues), 64.4 bits, see alignment E=3.1e-21 PF01584: CheW" amino acids 795 to 920 (126 residues), 87.1 bits, see alignment E=2.1e-28

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 96% identity to mmp:MMP0927)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (920 amino acids)

>MMJJ_RS00325 chemotaxis protein CheA (Methanococcus maripaludis JJ)
MDDMEQYKELFMTEAEEHLQSLNQNMVELENCPEDSERIINMIFRSAHTLKGSARTLGFE
HISSLTHHMEDILDYIRDGKIKVNPEIVDLLFKCLDALETMVSEVSDGEDTTSVDVDSLV
EVIKSVKEKYLSGENPKEDPLDCSDPNEVAKKQVEEKTVNNISSNSGSIHLVDESSIILI
EGQSNNFVVEKPENLDSVLNQMHESASALLTILDALEYSELKDTVKNIDELSTAMLNETV
AITENSLSVLKSALSTMQQIAKVVETGSSSNYDYSELNEKISITLSETVGESVDDKEIIL
DHTIFNLEEVSKELISEINENKKIYHVKSKVVEDCLLKAVRLTMVLSKLKEIGTIIASVP
AEENFLSSGSRELDVLISTDLDSIDILDSVCEMEYVVSTEVKFELETTVNQVADAEVLEK
EKSLETLAKFKINIKIDEECLLKAVRAYMVIKDLKEKGNVLETEPPEEKIQEGNLGGNTV
TIYYDSDESEDDIKEIISKTPEITEFLVNVQKNTNNSKDNTKIKNTVDATSKKQAENSSS
KKSQTVRVNIEKLDKLMNLVGEVVINRANFTQIATKYDLKELHNAVGRLNMLATELQEEV
MGMRMIPVAFVFNRFPRTVRDTAKALDKEIDFEIEGSDIELDRTVLDELAEPLTHLIRNS
LDHGIEHADERIKLGKPEKGILKLIATRQRDRVNIIIRDDGKGIDPDAMRKKAFEKGLYS
KEEAEKLTDNEAVNVIFLPGFSTAEVVSDVSGRGVGMDVVRSKIESLGGSVTVNSEVGKG
TEITLHLPLTMAIIQTLLIRLNEHIYALPLTSVLDVISVEKEQIKNLEGQEAIIYRNHIL
PVIWLKDALNTSGFSDSDDLYVVVVEKNKGKVGMILDEVIGRDEIVVKPLTGILKNINGL
AGATILGDGRVALILDLNNI