Protein Info for MMJJ_RS00130 in Methanococcus maripaludis JJ
Annotation: uroporphyrinogen-III C-methyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 74% identical to SUMT_METJA: Uroporphyrinogen-III C-methyltransferase (cobA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
KEGG orthology group: K02303, uroporphyrin-III C-methyltransferase [EC: 2.1.1.107] (inferred from 100% identity to mmp:MMP0966)MetaCyc: 54% identical to uroporphyrinogen-III C-methyltransferase subunit (Methanobacterium ivanovii)
Uroporphyrinogen-III C-methyltransferase. [EC: 2.1.1.107]; 2.1.1.107 [EC: 2.1.1.107]
Predicted SEED Role
"Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)" in subsystem Coenzyme B12 biosynthesis or Dissimilatory nitrite reductase or Experimental tye or Heme and Siroheme Biosynthesis (EC 2.1.1.107)
MetaCyc Pathways
- cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (14/15 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
- siroheme biosynthesis (4/4 steps found)
- cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) (10/13 steps found)
- adenosylcobalamin biosynthesis II (aerobic) (24/33 steps found)
- factor 430 biosynthesis (3/7 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.1.1.107
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (239 amino acids)
>MMJJ_RS00130 uroporphyrinogen-III C-methyltransferase (Methanococcus maripaludis JJ) MKVILVGAGPGDEGLITLKGVEAIKNADVIVYDDLIGEKLLKYAKTGSELIYVGKRKGKH SYKQEEINEILIDKAKENKNVVRLKGGDSFVFGRGGEEVLALKKEGIEYEMIPGITSSIS VPEIFGIPVTHRKVATSFTVVTGHEAGDKTEKEMQVKLSELNADTIVILMGITTLEKHVK ELLKNPKRNENTPVAILMDGTRENQRIVKGNLSNIVEKAKLENVCPPGIIIVGNVVDVL