Protein Info for LRK55_RS19010 in Rhodanobacter denitrificans MT42

Annotation: mercury(II) reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 574 PF00403: HMA" amino acids 5 to 55 (51 residues), 34.8 bits, see alignment 4.4e-12 TIGR02053: mercury(II) reductase" amino acids 112 to 574 (463 residues), 605.5 bits, see alignment E=3.8e-186 PF07992: Pyr_redox_2" amino acids 112 to 431 (320 residues), 226.7 bits, see alignment E=1.1e-70 PF13738: Pyr_redox_3" amino acids 243 to 415 (173 residues), 39.5 bits, see alignment E=1.1e-13 PF00070: Pyr_redox" amino acids 285 to 353 (69 residues), 51.7 bits, see alignment E=2.7e-17 PF02852: Pyr_redox_dim" amino acids 450 to 558 (109 residues), 105.2 bits, see alignment E=5.7e-34

Best Hits

Swiss-Prot: 76% identical to MERA_ACICA: Mercuric reductase (merA) from Acinetobacter calcoaceticus

KEGG orthology group: K00520, mercuric reductase [EC: 1.16.1.1] (inferred from 73% identity to nit:NAL212_0101)

Predicted SEED Role

"Mercuric ion reductase (EC 1.16.1.1)" in subsystem Mercuric reductase or Mercury resistance operon (EC 1.16.1.1)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.16.1.1

Use Curated BLAST to search for 1.16.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (574 amino acids)

>LRK55_RS19010 mercury(II) reductase (Rhodanobacter denitrificans MT42)
MNEQTLSVIGMTCADCARHVEKALRALPDVVAADVAYPQNVAHVRSTQPLTVEQLNAGLP
QNYRIAAASAPQADTLARKSSMLDQALGSLGGWFKPRGDVDRTPTASEQRLHVAVIGTGG
GAMAAALKAVELGARVTVIERGTVGGTCVNIGCVPSKIMIRAAHVAHLRRSSPFDDGISS
TGPVVRRDRLLAQQQGRVDELRHAKYEGILDTNPNIQLLRGEARFKDAHTLVVTSTTGRG
ESEVSFDRCLIATGAHAAVPPIPGLKDTPYWTSTEALASDAIPPRLAVIGSSVVAVELAQ
AFARLGSHVTILARSSLFFREDPAIGEAITAAFRAEGIEVLEHTQASQVAHANGEFVLTT
GHGEVRADRLLVATGRTANTRDLALEAAGVAVNAQNAIVVDRGMRTSAPHIYAAGDCTDQ
PQFVYVAAAAGTRAAINLMGGEATLDLTTMPAVVFTEPQVATVGLSEAEAHLQGIETDSR
TLSLDNVPRALVNFDTHGFIKLVAEAGSGRLIGVQAVTPEAGEIIQAAALAIRARMTVQE
LADQLFPYLTMVEGLKLAAQTFTKDVKQLSCCAG