Protein Info for LRK55_RS18865 in Rhodanobacter denitrificans MT42

Annotation: copper resistance system multicopper oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 592 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 9 to 591 (583 residues), 971.1 bits, see alignment E=2.1e-296 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 11 to 39 (29 residues), 28.5 bits, see alignment (E = 1.3e-10) PF07732: Cu-oxidase_3" amino acids 59 to 169 (111 residues), 128.7 bits, see alignment E=1.9e-41 amino acids 505 to 591 (87 residues), 24.3 bits, see alignment E=4.3e-09 PF00394: Cu-oxidase" amino acids 179 to 341 (163 residues), 86.9 bits, see alignment E=2.4e-28 PF07731: Cu-oxidase_2" amino acids 475 to 591 (117 residues), 107.5 bits, see alignment E=7.1e-35

Best Hits

Swiss-Prot: 63% identical to COPA_PSESM: Copper resistance protein A homolog (copA) from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

KEGG orthology group: None (inferred from 65% identity to net:Neut_0021)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (592 amino acids)

>LRK55_RS18865 copper resistance system multicopper oxidase (Rhodanobacter denitrificans MT42)
MNLFSPPPADLSRRRFVQGVAIGGAVAGLGLLRPSNVWALTNPGHPTVLSGTDFALDIAE
TPVNYTGATRLATTVNGGIPGPILRWKEGTTVNLRVTNRLRVPTSIHWHGIILPFQEDGV
PGISFDGIAPGETFLYQFKVRQSGTYWYHSHSGFQEQTGLYGPLVIEPAGPDRHPTDRDY
VVMLNDWTDENPERIFAKLKKQSDYYNFAQPTVPDFFRDVREKGLSQALAMRKMWNEMRM
NPTDFGDVSGYTYTYLMNGAAPAGNWTGIFKPGEKLRLRFINGSAQTIFDVRIPGLKMTV
ISADGQDIEPVSVDEFRISVAETYDVIVEPQEERAYTLFAQSIDRSGYARGTLAPRAGME
AEVPKPDPIQWLAMDDMMGAMAMGGSGHGSMQGMSGMSGMQGMAGMDHGAMPGMTDPAPP
VVRHARTEYGPGVDMHVDMPRTNLDDPGIGLRDNGRRVLTYADLHTIGGPIDAREPTREI
ELHLTGNMERFIWSFDGVKFSDAKPVHFNSGERLRIVLVNDTMMNHPIHLHGMWSEMENP
QGQFQVRKHTINVQPAQRITYAVSADNPGRWAYHCHLLYHMEAGMFREVVVS