Protein Info for LRK55_RS18840 in Rhodanobacter denitrificans MT42

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 782 transmembrane" amino acids 131 to 150 (20 residues), see Phobius details amino acids 161 to 180 (20 residues), see Phobius details amino acids 192 to 214 (23 residues), see Phobius details amino acids 230 to 248 (19 residues), see Phobius details amino acids 383 to 405 (23 residues), see Phobius details amino acids 411 to 433 (23 residues), see Phobius details amino acids 727 to 747 (21 residues), see Phobius details amino acids 753 to 774 (22 residues), see Phobius details PF04945: YHS" amino acids 27 to 70 (44 residues), 45.5 bits, see alignment 1.5e-15 PF19335: HMBD" amino acids 86 to 112 (27 residues), 47.7 bits, see alignment (E = 3e-16) TIGR01511: copper-translocating P-type ATPase" amino acids 174 to 776 (603 residues), 575.7 bits, see alignment E=2.4e-176 TIGR01525: heavy metal translocating P-type ATPase" amino acids 193 to 776 (584 residues), 620.9 bits, see alignment E=5.2e-190 TIGR01512: cadmium-translocating P-type ATPase" amino acids 229 to 777 (549 residues), 383.2 bits, see alignment E=3.7e-118 TIGR01494: HAD ATPase, P-type, family IC" amino acids 237 to 746 (510 residues), 284.4 bits, see alignment E=2.7e-88 PF00122: E1-E2_ATPase" amino acids 266 to 446 (181 residues), 192.9 bits, see alignment E=9.4e-61 PF00702: Hydrolase" amino acids 464 to 681 (218 residues), 112.5 bits, see alignment E=8.9e-36 PF08282: Hydrolase_3" amino acids 653 to 710 (58 residues), 22.1 bits, see alignment 2.9e-08

Best Hits

Swiss-Prot: 58% identical to COPA_LEGPH: Copper-exporting P-type ATPase (copA) from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 74% identity to sml:Smlt2440)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (782 amino acids)

>LRK55_RS18840 heavy metal translocating P-type ATPase (Rhodanobacter denitrificans MT42)
MNTRHHHTGANKHGHGAHPGSATTALDPVCGMRVDPNQTAYHAEYQGVTRHFCSARCRER
FVADPAKYLSGQPDDASAEAPAGTMYICPMHPQVRQEDPGICPICGMALEPEMPGLDDED
QPELRDFSRRFWWTLPATLVVLVLAMFGHYLPRLPVNTRTWIELVLTMPVVLWAGWPFFV
RCVQSVRNLSPNMWTLIGIGVGAAFGYSIVATLAPDVFPESFHEHGRVGVYFEAAAVIVS
LTLLGQLLELRARSKTSTALKALLGLAPKTARRLRDDGGEEDVELGNVHVGDRLRVRPGE
KVPVDGEVIEGRSLVDESMLTGEPVPVEKSIGSSVIGATLNGTGSLVIRAEKVGSATVLS
QIVQLVAQAQRSRAPMQRMADKVAFWFVLAVLAIAVATFVVWGLFGPEPSWTFAVLNAIS
VLIIACPCALGLATPMSIMVATGRAAGEGVLFRDAEAIENLRKIDTLIVDKTGTLTEGRP
AFHTALAAKGFTEHEVLRLAASLDQGSEHPLADAIVAEARHRGLALETPESFESSTGIGV
RGKVGGATLAIGNTALMDEVGVDATVLSVPAEKLRRAGASVMYLAVDGVLAGLLAVADPI
KATTADAIASLHDAGLKIVMATGDGATTAHAVARTLGIDEVHGEVRPKDKIDLVQQLQAK
GHRVAMAGDGINDAPALAGADVGIAMGTGTDVAMSSAQVTLVKGDLRGIVRARSISNDTV
ANMKQNLGFAFLYNALGVPVAAGVLYPLTGLLLSPMIAALAMSLSSVSVVANALRLGRKR
HG