Protein Info for LRK55_RS18820 in Rhodanobacter denitrificans MT42

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1058 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 338 to 357 (20 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 443 to 466 (24 residues), see Phobius details amino acids 484 to 505 (22 residues), see Phobius details amino acids 538 to 557 (20 residues), see Phobius details amino acids 874 to 891 (18 residues), see Phobius details amino acids 898 to 918 (21 residues), see Phobius details amino acids 924 to 948 (25 residues), see Phobius details amino acids 983 to 1002 (20 residues), see Phobius details amino acids 1014 to 1036 (23 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1046 (1046 residues), 1305.4 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1036 (1031 residues), 786.6 bits, see alignment E=1.7e-240

Best Hits

Swiss-Prot: 61% identical to CUSA_ECOL6: Cation efflux system protein CusA (cusA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 65% identity to aex:Astex_3842)

MetaCyc: 61% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1058 amino acids)

>LRK55_RS18820 efflux RND transporter permease subunit (Rhodanobacter denitrificans MT42)
MIAALIRAAIAHRVFVLLAALALAAVGVFSALHTSIDALPDLSDTQVIIRTSYPGQSPQV
VEDQVTYPLATTMLSVPGATTVRAFSFFGDSYVDVLFDDSTDLYWARSRVLEYLSQARDR
LPAGVTPALGPDATGLGWIYEYALIDRTGQHDLGQLRALQDWFLRYQLKTVPNVAEVATL
GGMERAWQIVPDPQALAARGITVAQLVDAVRSANGANGGSVIEQGEAELMVRSEGYLKSR
TDFENVPITTNAGGVPVLLHDVATVRRGPTFRRGLAELDGQGEVVGGIIVMRTGKNAKAT
IAAVKSRLAELQRSLPAGVEIVPTYDRSRLIDAAVENLWGKLLEEFLIVALVCVLFLGHL
RSALVAVITLPLGVLTAFIVMNLQGVSANLMSLGGIAIAIGAMVDAAIVMIENTHKHLEH
WRSANDGREPQGAQRWSLIADAAAEVGPALFVSLLIIALSFVPVFALQGQEGKLFKPLAF
TKTYAMAAAAGLAVTLVPVLMGYLIRGRIRAERDNPLNRGLIRGYRPLLEAVLRHPKATL
VLAGVLLLTAIIPMTRLGSEFMPAMDEGTLLYMPTALPGLSAGKASQLLQLTDRMIKTVP
EVDHVFGKAGRADTATDPAPLEMFETTITFKPKDQWRPGMTMDKIKAELDKAVHVPGLTN
LFVPPIRNRIDMLSTGIKSPIGIKVLGTDLAALQTVADRIETVAKTVPGVSSAIAERPTS
GRYVDVAIRRDAAARYGLTQERVQQLIATVVGGDPIGQTVEGRERYPIVVRYPRAERDSV
EALRRLPIVAANGAQLALSQVADIAVVAGPSMLKSEGGQLATYVYVDTAGSDLGTVVANL
QRAVAQQVTLPPGTTVAWSGQFEYLASAMERLKVVVPIALVIIFLLIYAVFRRMSEAALI
MASVPLALVGGLWLIWLLGHAVSVATIIGFIALAGVAAEFGVVMLLYLRQAWDRQLVRDP
QAGLNALDEAIREGAVQRVRPKAMTVAVILAGLFPILLGHGAGSEVMQRIAAPMIGGMVT
APLLSMLVIPAAYRLLVRHRLRKASKANATLHPNPQGN