Protein Info for LRK55_RS18770 in Rhodanobacter denitrificans MT42

Annotation: ACR3 family arsenite efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 362 transmembrane" amino acids 27 to 46 (20 residues), see Phobius details amino acids 59 to 78 (20 residues), see Phobius details amino acids 99 to 121 (23 residues), see Phobius details amino acids 134 to 155 (22 residues), see Phobius details amino acids 170 to 192 (23 residues), see Phobius details amino acids 199 to 217 (19 residues), see Phobius details amino acids 237 to 255 (19 residues), see Phobius details amino acids 261 to 286 (26 residues), see Phobius details amino acids 299 to 322 (24 residues), see Phobius details amino acids 328 to 350 (23 residues), see Phobius details TIGR00832: arsenical-resistance protein" amino acids 22 to 349 (328 residues), 383.1 bits, see alignment E=5.9e-119 PF01758: SBF" amino acids 67 to 262 (196 residues), 116.9 bits, see alignment E=4.6e-38

Best Hits

Swiss-Prot: 50% identical to ACR3_ALKMQ: Arsenical-resistance protein Acr3 (acr3) from Alkaliphilus metalliredigens (strain QYMF)

KEGG orthology group: K03325, arsenite transporter, ACR3 family (inferred from 78% identity to sml:Smlt0176)

Predicted SEED Role

"Arsenical-resistance protein ACR3" in subsystem Arsenic resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (362 amino acids)

>LRK55_RS18770 ACR3 family arsenite efflux transporter (Rhodanobacter denitrificans MT42)
MNQLSAEVVDADPDTASGSRIGFFERYLTVWVLLCIVVGTLLGHWLPDTFEALGGMQVAQ
VNLPVAVLIWLMIIPMLLKIDFSALGGVRRQWKGIGVTLFINWAVKPFSMALLGWIFIRH
VFAGYLPADQLDSYIAGLILLAAAPCTAMVFVWSNLCHGEPNFTLSQVALNDTIMVVAFA
PIVALLLGISSITVPWNTLLLSVLLYIVVPVAISVVLRRWVLSRGGEPQLQKLLQRLGPA
SLFALLATLVLLFGFQGQQILAQPAVIAMLAVPILIQVYFNSGLAYVLNRRFGVPHCVAG
PSALIGASNFFELAVATAVGLFGVHSGAALATVVGVLIEVPVMLSVVRIVNGSKRWYELK
QA