Protein Info for LRK55_RS18670 in Rhodanobacter denitrificans MT42

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1027 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 334 to 354 (21 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 390 to 412 (23 residues), see Phobius details amino acids 433 to 456 (24 residues), see Phobius details amino acids 468 to 495 (28 residues), see Phobius details amino acids 527 to 546 (20 residues), see Phobius details amino acids 860 to 881 (22 residues), see Phobius details amino acids 888 to 908 (21 residues), see Phobius details amino acids 918 to 939 (22 residues), see Phobius details amino acids 960 to 979 (20 residues), see Phobius details amino acids 991 to 1014 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1015 (1015 residues), 1056.8 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1017 (1012 residues), 978.8 bits, see alignment E=1.5e-298

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 76% identity to app:CAP2UW1_4536)

MetaCyc: 43% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1027 amino acids)

>LRK55_RS18670 CusA/CzcA family heavy metal efflux RND transporter (Rhodanobacter denitrificans MT42)
MLNRLIQFALAQRLFVLLAAALLAAAGWFAFQHLPIDAFPDVSSTQVKVIMKAPGMTPEE
IETRIAIPIEVEMLGIPDQRMLRSVSKYGLVDVTIDFQDGTDIYWARQQVAERLNGILAD
LPEGISGGMAPITTPLGEMFMFTVEAENMSITERRSLLDWVIRPALRAVPGVADVNALGG
LVRSYEVVPDPVKLAAVGLSTNDLQAAIGANNRNDGAGRLSEGDEVLLVRTEGNIRHLDD
LRAIVVTRKDGVPVRMGDVAEVRIGALTRYGVVTKDGRGEAVEGLVLGLAGANARDVVSG
VEKKLAELAPSLPAGVKLQVFYNRADLVNKAVGTVTKALIEGTLLVLVLLGAFLGNVRAA
ITVAVVLPLAALATFILMRVGGMSANLMSLGGLAIAIGMLVDAAVVVVENIVQHLAHDKA
GGKLPRLHIIFRAVREVAVPVTAGILIIITVFLPLLTLQDLEGKMFVPVALTIAFALASS
LVLSLTVIPVLASFLLRKVPRDDPWLPRKLLAAYRPALAWAMRRQRVVFIAAGVMLAVTI
GVYVMVGKTFMPTMNEGDLIVGIEKLPSVSLEESAALDLKIQQALMSKVPEIIGVVARAG
SDEIGLDPMGLNQTDTFLVLKPTNEWQAKDKGALITKIRGVLDELPGIKYSFTQPIDMRV
QEMIIGVRGDLAIKVFGPDLAILDELASQIEAQVKTVPGNQDVYTVQNDGVQYLRVIVDR
LAAGQFGLSVEDVQDALRAQIEGQRAGLVIEGNQRVPIVLRGPERVKLSPAEFAMLRITA
ADGTSVPLESVARLVRDGGPVKIDREMGSRYSVVIANVSGRDLVGFVKEAKAKIAKAVSL
PTGYRISWGGQFENQQRAAARLTLVVPLALGVIFLILFSTFGSVRQSLLVLSNIPFALMG
GVIALWVTGEYLSVPASVGFIALLGIAVLNGVVLVSYFNQLHAEGLSRLQCVVVGAERRL
RPVMMTASITAFGLIPLLFASGPGSEVQRPLAIVVIGGLVTATALTLILLPILYLRFAHA
TAEVCHG