Protein Info for LRK55_RS17465 in Rhodanobacter denitrificans MT42

Annotation: flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00612: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
  • amino acids 17 to 406 (390 residues), 388.8 bits, E=1.3e-120
• PF04551: GcpE
  • amino acids 22 to 406 (385 residues), 368.3 bits, E=1.8e-114

Best Hits

Swiss-Prot: 76% identical to ISPG_STRM5: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG) from Stenotrophomonas maltophilia (strain R551-3)

KEGG orthology group: K03526, (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC: 1.17.7.1] (inferred from 77% identity to psu:Psesu_1345)

Predicted SEED Role

"1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (EC 1.17.7.1)" in subsystem Isoprenoid Biosynthesis (EC 1.17.7.1)

MetaCyc Pathways

• methylerythritol phosphate pathway II (9/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.7.1

Protein Sequence (419 amino acids)

>LRK55_RS17465 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (Rhodanobacter denitrificans MT42)
MSEFVPQKPHPAAPAPRRPSVAVQIGKVTVGGGAPVVVQSMTNTDTEDPASTAKQVAELA
RAGSELVRITVNTPAAAAAVPRIAERLAMMGVEVPIVGDFHYNGHQLLEREPACAEVLAK
YRINPGNVGFGKKKDSQFGAIIEKAIQYGKPVRIGANWGSLDQGMLTALMDENARRAEPW
DASHVAREALIRSALDSAALAEKIGLPRERIILSCKVSGVQELIAVYRDLAARCDYALHL
GLTEAGMGSKGITASSAALAVLLQEGIGDTIRISLTPEPGASRTGEVIVAQELLQTMGLR
SFTPLVTACPGCGRTTSEFFQELAKTVQEHVREQMPVWRIKYDGVENLTLAVMGCIVNGP
GESKHANIGISLPGNGEAPAAPVFIDGEKAMTLRGDRIAEEFVGILDDYVARRYAARTG