Protein Info for LRK55_RS17330 in Rhodanobacter denitrificans MT42

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1044 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 343 to 365 (23 residues), see Phobius details amino acids 372 to 392 (21 residues), see Phobius details amino acids 398 to 419 (22 residues), see Phobius details amino acids 453 to 471 (19 residues), see Phobius details amino acids 485 to 508 (24 residues), see Phobius details amino acids 539 to 558 (20 residues), see Phobius details amino acids 873 to 894 (22 residues), see Phobius details amino acids 901 to 924 (24 residues), see Phobius details amino acids 930 to 951 (22 residues), see Phobius details amino acids 973 to 992 (20 residues), see Phobius details amino acids 1004 to 1027 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1040 (1040 residues), 1121.7 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1029 (1024 residues), 970.2 bits, see alignment E=5.9e-296

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 68% identity to app:CAP2UW1_4548)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1044 amino acids)

>LRK55_RS17330 CusA/CzcA family heavy metal efflux RND transporter (Rhodanobacter denitrificans MT42)
MLERLVEFSLRYKVLVLIIFVVIGFLGFQAVRQLPIDAFPDVTPVQVNVYTEASGLAAED
VEQLLTTPVESALAGLPKVEQIRSVSLFGLSYVSVYFDDSMDIYFARQLVNERLQQVGDR
LPVGYGKPEMGPNTSGLGQVFWYTVERADDTLKGTTAGTATNDMDLRTLQDWTIRLILRT
APGVDDVSSWGGQEKQFQVRIDPMKLIAHKLGFKNVIEALQANNAQVGGNFVDVGREQYL
VRGLGLIQNAKDLGNIVLKTEDGTPVYVRDVATITEAGAPRTGAVTRDGKEVVLGMALAR
IGENAKSVVDAVKAKLDTVKQSLPPGVVVKPVYERTELVNAAVGTAVRALVEGSILVALV
LFLFLGEFRSALVVVVALPLAMLIAFICMNQVGLSANLMSLAGLAIGIGMMVDGAVVMVE
NAYRIMAERKAHGGPVDRTAAVLAAAREVANPMAFAILIIIVVFLPLFSLQGLEGKMFKP
MAFNISFAMAGSLILALTLIPVLAALVLKPKEEKDTWLVAFLKRHYATVLTWALARRKLV
LGIAAGALVGSLALFPFLGKEFMPNLKEGAIMWRITSIPSASLDESIDISKQVSTLVKQK
FPEVETTLAMIGRAEKGETADVNYMEVYTPLKPKDQWRKGETLESIEEAMQKELSAALPT
AVVSYTQPIQMRIEELISGVRATLALKIYGDDLGELDRLSGRIKNVLVGVPGVADLALEA
NIGKPQIRIKVDRDALARYGLNADDVLTVVKNGIGGEPVTTLLDGVKRFDIAVRLDDADK
ASLPAIQRIPIRTASGALVQLSQVAEVSDAEGYSFIRREQLQRYAVIQMDVRGRDIDGFV
KEANDAIAQQVKLPTGYYSEWGGAFENQQRALARLSLIVPATIFFIFVLLYTAFNSVKYA
ALILANVPFATIGGIVGLAITGQYLSVPSAIGFIAVFGVAMLNGIVLVSFLNEQREKGLP
VRDAVIRGTALRMRPVMMTASVAILGLVPMLLSSGVGAETQRPLATVVVGGLITSTLLTL
VLLPVLYDWIEERAARRSAKENTP