Protein Info for LRK55_RS16970 in Rhodanobacter denitrificans MT42

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1044 signal peptide" amino acids 1 to 14 (14 residues), see Phobius details amino acids 28 to 31 (4 residues), see Phobius details transmembrane" amino acids 15 to 27 (13 residues), see Phobius details amino acids 346 to 365 (20 residues), see Phobius details amino acids 372 to 392 (21 residues), see Phobius details amino acids 398 to 419 (22 residues), see Phobius details amino acids 451 to 470 (20 residues), see Phobius details amino acids 485 to 508 (24 residues), see Phobius details amino acids 539 to 558 (20 residues), see Phobius details amino acids 875 to 894 (20 residues), see Phobius details amino acids 901 to 924 (24 residues), see Phobius details amino acids 930 to 951 (22 residues), see Phobius details amino acids 973 to 992 (20 residues), see Phobius details amino acids 1004 to 1027 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1037 (1037 residues), 1126.8 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1029 (1024 residues), 972.2 bits, see alignment E=2.9e-296

Best Hits

Swiss-Prot: 43% identical to CZCA_CUPMC: Cobalt-zinc-cadmium resistance protein CzcA (czcA) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 67% identity to app:CAP2UW1_4548)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1044 amino acids)

>LRK55_RS16970 CusA/CzcA family heavy metal efflux RND transporter (Rhodanobacter denitrificans MT42)
MLERLVEFSLRYKVLVLIAFVVIGFLGVQAVRQLPIDAFPDVTPVQVNVYTEASGLAAED
VEQLLTTPVESALAGLPKVEQIRSVSLFGLSYVSVYFDDSMDIYFARQLVNERLQQVGDR
LPAGYGKPEMGPNTSGLGQVFWYTVERADDKLKGATAGTAPNDMDLRTLQDWTIRLILRT
APGVDDVTSWGGQEKQFQVRIDPMKLIAHKLGFKGVIEALQANNAQVGGNFVDVGREQYL
VRGLGLIQNAKDLGNIVLKTEDGTPVYVRDVATITEAGAPRTGAVTRDGKEVVMGQALAR
IGENAKSVVDAVKAKLDTVKQALPPGVVVKPVYERTELVNAAVETAVRALIEGSILVAII
LFLFLGEFRSAIVVVVALPLAMLIAFICMGQVGLSANLMSLAGLAIGIGMMVDGAVVMVE
NAYRIMAERKAHGLPVDRTAAVLAAAREVANPVAFAILIIIVVFLPLFSLQGLEGKMFKP
MAFNISFAMAGSLILALTLIPVLAALVLKPKEEKDTWLVAFLKRHYATVLAWALARRKLV
LGIAAGALIGSLALFPFLGKEFMPNLKEGAIMWRITSIPSASLDESIAISRQVSTLVKQK
FPEVETTLAMIGRAERGDTADVNYMEVYTPLKPKEQWRKGETLESIEEAMQKELSAALPT
AVVSHTQPIQMRIEELISGVRATLALKIYGNDLGELDRLSRRIKDVLAGVPGVADLALEA
NIGKPQIRIKVDRDALARYGLNADDVLTVVKNGIGGEPVTTLLDGVKRFDIAVRLDDADK
ASLPAIQRIPIRTPSGALVQLSQVAEVSDVEGYSFIRREQLQRYAVIQMDVRGRDIDGFV
KDANAAIAQQVKLPTGYYSEWGGAFENQQRALKRLSLIVPATIFFIFVLLYTAFNSVKYA
ALILANVPFATIGGIVGLAITGQYLSVPSAIGFIAVFGVAMLNGIVLVSFLNEQREKGLP
VREAVIRGTALRMRPVMMTASVAILGLVPMLLSSGVGAETQRPLATVVVGGLITSTLLTL
VLLPVLYDWIEERAARRLAKENTP