Protein Info for LRK55_RS15980 in Rhodanobacter denitrificans MT42

Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 420 TIGR01224: imidazolonepropionase" amino acids 29 to 405 (377 residues), 481.8 bits, see alignment E=6.3e-149 PF01979: Amidohydro_1" amino acids 66 to 390 (325 residues), 75.8 bits, see alignment E=4e-25 PF07969: Amidohydro_3" amino acids 219 to 407 (189 residues), 59 bits, see alignment E=6.2e-20

Best Hits

Swiss-Prot: 62% identical to HUTI_RHORT: Imidazolonepropionase (hutI) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 67% identity to psu:Psesu_2247)

MetaCyc: 61% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (420 amino acids)

>LRK55_RS15980 imidazolonepropionase (Rhodanobacter denitrificans MT42)
MNDPRWDRLLLNATLATFADDTPYGLIRHGAIALHHGRITWVGRQDELPDAPDALAATVE
SLDGALVTPGLIDCHTHLVFGGNRAHEFELRLNGASYEDIARAGGGIASSVNATRAASEQ
QLFEQSLPRARALLADGVTTLEIKSGYGLELDSERRMLRVARRLGRELSITVRTSFLGLH
ALPPEYKDRRDEYVALVCDDMLPTLAAEGLVDAVDAFCEGIGFSREETRRVFERARQLGL
PVKLHAEQLSDLGGAALVAEYGGLSADHLEHLSEAGIAAMAQAGTVAVLLPGAFYALRET
QLPPVAALREQRVPIAIATDCNPGTSPLLSLRLAAGMACTLFRLSPEEALRGVTVNAARA
LGQRDRGTLAAGQRADLVVWNARQPAELCYWIGGGLARRVYVAGEPVSRRKPPNRSTSAA