Protein Info for LRK55_RS14545 in Rhodanobacter denitrificans MT42

Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 PF02518: HATPase_c" amino acids 30 to 182 (153 residues), 27.2 bits, see alignment E=6.7e-10 PF13589: HATPase_c_3" amino acids 30 to 165 (136 residues), 35.5 bits, see alignment E=1.5e-12 PF00183: HSP90" amino acids 220 to 620 (401 residues), 437.9 bits, see alignment E=9.8e-135

Best Hits

Swiss-Prot: 58% identical to HTPG_BORBR: Chaperone protein HtpG (htpG) from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 76% identity to psu:Psesu_3037)

MetaCyc: 54% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (622 amino acids)

>LRK55_RS14545 molecular chaperone HtpG (Rhodanobacter denitrificans MT42)
MNAPAETRKFEAEVAQVLHLVTHSLYSHKEIFLRELISNASDACDKLRFESIAKPELSAG
DSELHIDVSWDPAARTVTVRDNGIGMNRDEVVANIGTIASSGTRRFLEAMSGEQKADARL
IGQFGVGFYSAFVVADKVTVLSRRADAPAGEGVKWESDGKGEYSLEPVELAERGTAVILH
LKADEDEFLSRWQLRALITRYSDHVAFPIRMPVEKDGKPTDEFETINAASALWTKPKSEI
SDEDYQSFYKSLGHDFNDALAWTHNRVEGSQSFTTLLYIPSQPPFDLMMGGRDERKGVKL
YIKRVFIMDAAEELLPNYLRFVRGVVDADDLPLNVSREILQHNRQLERIKAACVKRVLDL
IEKLAKDEPEKFATFYKAFGNTLKEGISEDANNRERIAKLLRFASTKGEGSQQTVALDDY
IGRMAVGQDAIWYITADSYAAAFGSPQLEAFKAKDIEVLLMSDRIDEWMIGSLSEYEGKK
LKSVAKGEVPLDEAGKKKQEEATKEAAPLLKKLKDLLGDRVADVKVSARLTDSPSCLALS
DYEMAPHLARLLREAGHEMPENKPTLEINPQHALLKRVEAEADEAKAKDLATLLLEQAEI
AAGAQLPDPSAFVQRMNRVLLG