Protein Info for LRK55_RS14135 in Rhodanobacter denitrificans MT42

Annotation: multidrug effflux MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 421 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 48 to 68 (21 residues), see Phobius details amino acids 78 to 102 (25 residues), see Phobius details amino acids 107 to 124 (18 residues), see Phobius details amino acids 136 to 161 (26 residues), see Phobius details amino acids 167 to 186 (20 residues), see Phobius details amino acids 215 to 235 (21 residues), see Phobius details amino acids 252 to 271 (20 residues), see Phobius details amino acids 283 to 304 (22 residues), see Phobius details amino acids 316 to 335 (20 residues), see Phobius details amino acids 347 to 367 (21 residues), see Phobius details amino acids 373 to 393 (21 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 13 to 390 (378 residues), 216.9 bits, see alignment E=3.2e-68 PF07690: MFS_1" amino acids 18 to 357 (340 residues), 163.1 bits, see alignment E=9e-52 PF00083: Sugar_tr" amino acids 51 to 189 (139 residues), 23.9 bits, see alignment E=1.9e-09

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 50% identity to psu:Psesu_2163)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (421 amino acids)

>LRK55_RS14135 multidrug effflux MFS transporter (Rhodanobacter denitrificans MT42)
MNPAHRPVRRSLPWLLAALSMIGPFSIDAVFPAFPLVGAHFGVDAAPLQQLISVYLVTYA
AMSLFHGAISDAVGRKPVVVAGLLVYALASVGAAMSTSFAMLLACRGLQGMCAGAGLVVG
RAVVRDSLEGPAAQRLMSQVMMIFGVAPVIAPMVGALLLPLGGWHGIFWLLAGFTVLLAL
ALQLFLDETHPPARRTRFAPRPLLAGYRSFGRDRLFWPLLVSSSVNFAGLFLYIASAPRI
VRELLQLSAQGFPWLFLPVVSGLIGGAWLSGRMAGRHSANSTVSLGYAVMLLACAAHLLL
ALLLPAPRLPWSMLPLILHGIGVQLAFPTLTLLLLDRFPHHRGGISSVQAFASLLLCSFV
AGVMSPLLSRGMLPLALGASALTVAGVLAWWWYHRLTRRSLELPLADAGTAAMQAEIAEP
R