Protein Info for LRK55_RS11160 in Rhodanobacter denitrificans MT42

Annotation: D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08013: GatZ_KbaZ-like
  • amino acids 4 to 424 (421 residues), 607.1 bits, E=7.6e-187
• TIGR02810: D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit
  • amino acids 6 to 424 (419 residues), 618.7 bits, E=2.6e-190

Best Hits

Swiss-Prot: 51% identical to KBAZ_ENT38: D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ) from Enterobacter sp. (strain 638)

KEGG orthology group: K00917, tagatose 6-phosphate kinase [EC: 2.7.1.144] (inferred from 61% identity to cak:Caul_0317)

MetaCyc: 52% identical to putative tagatose-1,6-bisphosphate aldolase 1 chaperone (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Tagatose-6-phosphate kinase (EC 2.7.1.144) / 1-phosphofructokinase (EC 2.7.1.56)" in subsystem Fructose utilization or D-Tagatose and Galactitol Utilization or Lactose and Galactose Uptake and Utilization (EC 2.7.1.144, EC 2.7.1.56)

MetaCyc Pathways

• superpathway of hexitol degradation (bacteria) (14/18 steps found)
• fructose degradation (1/1 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (3/4 steps found)
• N-acetyl-D-galactosamine degradation (3/5 steps found)
• galactitol degradation (3/5 steps found)
• lactose degradation I (2/5 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Galactose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.144 or 2.7.1.56

Protein Sequence (429 amino acids)

>LRK55_RS11160 D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit (Rhodanobacter denitrificans MT42)
MDVLLDLIARHKQGHASGVTSICSAHPIVIEASLRHAQRSGQAFALFEATCNQVNQDGGY
TGMTPADFVAFIHAIADRVGFDHARIALGGDHLGPNPWTSLDAAAAMDKAEVMVGAYVAA
GFRKIHLDCSMACRGDPEPLPEAEIVRRAVRLCRAAEAAHAGAGDEAPVYVIGTEVPVPG
GATESIDGLAVTTPQAALATIEAHRQAFIAAGLASAWQRVIASVVQPGVEFDHHDVVDYQ
PQKARELSEAITGVPGMVFEAHSTDYQTRDALGSLVRDHFAILKVGPGLTFALREAFWAL
DAIEQAWIEDARRARLREVVLARMREQPGYWQRYYHSRDHALTVDLQYSLSDRIRYYWPD
PAIEQACQRLFDNLRANPPPIPLISQFLPHALHALRIGSATRDPLSLTMAHVSAALDDYH
HACHDHDTH