Protein Info for LRK55_RS10715 in Rhodanobacter denitrificans MT42

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 983 PF13185: GAF_2" amino acids 172 to 317 (146 residues), 36.1 bits, see alignment E=1.8e-12 amino acids 376 to 510 (135 residues), 44.5 bits, see alignment E=4.8e-15 PF01590: GAF" amino acids 250 to 315 (66 residues), 26.3 bits, see alignment 2.4e-09 amino acids 377 to 511 (135 residues), 39.3 bits, see alignment E=2.3e-13 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 552 to 717 (166 residues), 145.4 bits, see alignment E=6.5e-47 PF00990: GGDEF" amino acids 557 to 714 (158 residues), 162.8 bits, see alignment E=1.5e-51 PF00563: EAL" amino acids 735 to 969 (235 residues), 227.4 bits, see alignment E=4.2e-71

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (983 amino acids)

>LRK55_RS10715 EAL domain-containing protein (Rhodanobacter denitrificans MT42)
MKHAGAVGSMSYEGSLQLGWLARLTAAHAPDEVAGAIAELARALPGCSAACVLWGLDDGA
TWRSVPPLPAAMDEAWLAGAVRATAPHRHPDGSRVAVRLCVQPQPALLLLQLDEPAAGGF
FDDLEAPLRLAGQHLRRALEWAELQDSHEQLERSEALQRALFAISDLAGSERDMPDMLRG
IHAIVSTLMYAENFFIVLHDVARSTIRFLYFVDVESPPLFEVGRDLPLSAIEHTLTWHVI
SDGKARMGDAEELRSQVAGPVTLIGPDSHDWLGVPMLRGSQPCGVLVVQSYRPDIGFTDE
DLALLQFVGSHILTALERKQGKDELEQRVQLRTLQLAEANRGLQQEIVERQRAEHLQAAL
FQIAELATADIDQGAFYRRVHAVVGELLNAQNFFIGLLSDDGRKLSFPYSVDAVLAPPAE
RVLARGLSEYVLRLGRALRVDNADIEELERRGEIAPGRMNSPAMYWLGVPLIVADEVIGL
VAVQSYRADVVYGAADQELLSFVASQVANSLTRRRSAESLKRAYEQLEQRVEERTQALRK
EIGERERMQDQLRHQVMHDALTGLPNRGYLRDRIERVLAAMRREPQQQCALLYLDVDRFK
IINDSLGHLAGDEVLKEVAKRLSSCVRHPDLVARLSGDEFAILLEQDDLPSAATAVAQRV
LDALDAPMPVAGKELQVTASVGIAIGDGHYAAADELLRDADIALYRAKELGRKRYELFDE
RLAQTVVDVLALEGELRQALLHGQFEPYFQPICALDGSHRTLGYEALLRWNHPQRGVLRP
GDFLKIAEDSGLIETIDWHLFELSCRLLLQHERNDSFMTVNVSALHLRHAHFDRRLIQLL
EHIGLPPSRLVVEVTEGALLDNPEYVRATLERLRAIGIGAALDDFGTGYSSLSYLHSLPL
RILKIDRAFVQELDKGANTSSTTVVAAILALARALNIQVIAEGIETPAQRDALMAMGCEM
GQGYLLGRPAPIAQWRESRAVDA