Protein Info for LRK55_RS09305 in Rhodanobacter denitrificans MT42

Annotation: Hg(II)-responsive transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 135 PF13411: MerR_1" amino acids 9 to 75 (67 residues), 62.1 bits, see alignment E=6.5e-21 PF00376: MerR" amino acids 9 to 46 (38 residues), 51.2 bits, see alignment E=1.3e-17 TIGR02051: Hg(II)-responsive transcriptional regulator" amino acids 10 to 132 (123 residues), 168.2 bits, see alignment E=4.5e-54 PF09278: MerR-DNA-bind" amino acids 51 to 112 (62 residues), 64.9 bits, see alignment E=1.3e-21

Best Hits

Swiss-Prot: 66% identical to MERR_PSEAI: Mercuric resistance operon regulatory protein (merR) from Pseudomonas aeruginosa

KEGG orthology group: K08365, MerR family transcriptional regulator, mercuric resistance operon regulatory protein (inferred from 74% identity to adn:Alide_1829)

Predicted SEED Role

"Mercuric resistance operon regulatory protein" in subsystem Mercury resistance operon

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (135 amino acids)

>LRK55_RS09305 Hg(II)-responsive transcriptional regulator (Rhodanobacter denitrificans MT42)
MNSAQDNLSIGTFAKASGVGVETIRFYQRRGLLPEPERPLGGIRRYSHADVARVKFVKSA
QRLGFSLDEVAQLLTLEDGTHCSEAAEFAARHLADVRARLKDLKRMETALSRLVTQCGSH
RGAISCPLIASLHGG