Protein Info for LRK55_RS08900 in Rhodanobacter denitrificans MT42

Annotation: arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 4 to 623 (620 residues), 816.8 bits, E=6.5e-250
• PF02784: Orn_Arg_deC_N
  • amino acids 90 to 340 (251 residues), 137.8 bits, E=6.3e-44
• PF17810: Arg_decarb_HB
  • amino acids 365 to 442 (78 residues), 54.9 bits, E=1.4e-18
• PF17944: Arg_decarbox_C
  • amino acids 576 to 623 (48 residues), 48.7 bits, 1.3e-16

Best Hits

Swiss-Prot: 60% identical to SPEA_XANAC: Biosynthetic arginine decarboxylase (speA) from Xanthomonas axonopodis pv. citri (strain 306)

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 61% identity to sml:Smlt4364)

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• superpathway of arginine and polyamine biosynthesis (12/17 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• spermidine biosynthesis III (2/4 steps found)
• superpathway of putrescine biosynthesis (2/4 steps found)
• superpathway of polyamine biosynthesis I (4/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (4/13 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Protein Sequence (650 amino acids)

>LRK55_RS08900 arginine decarboxylase (Rhodanobacter denitrificans MT42)
MSRWTTKRANQTYAIPHWSNGYVDVARSGHLLILPRRDKGAALDLPTIVNQATSEGLRLP
LLVRFPDILADRLDHLRRAFAGAIEHANYPGSYIAVYPIKVNQQKSVVSKLVAAGEEGFG
LEAGSKPELMAVLACARPGSVVVCNGYKDREYIRLALTGRKLGLRVHIVIEKLTELDHIF
REAKSLDVEPLLGVRVRLASIGAGKWQNSGGSKSKFGLSSGQVLELVERLDAANLKHTLR
LQHFHMGSQISNVHDIAAGMREAARYFVDLHQLGVPIDIVDVGGGLGVDYDGTRSRSFNS
ISYSLDEYAAAIVQPLAKAVAEHGLTAPVLCTESGRAMTAHHAVMVVNVSEVERASDGGI
PDARPDEPATLRSMRELLAESDARPAREIIHDANRLLSTGQDLYALGKIDLHERARLDEL
FHAIAKAVRMRPRPDGRALREAENDLYETLVDKYFVNFSVFESVPDVWAIDQVFPIVPIS
RLDEEPTRRGVIVDLTCDSDGRIDHYVNAQGVDVNLPLHAMEDDRPYRLGIFMVGAYQET
LGDIHNLFGDTDAVDVHVTANGYAFTHIRRGDTTDVMLDYVGYDPKQLREQYADRLAAAG
TRGSEAKTFLEILDKGLTGYTYLAETMVPEATGIPSTQPCTAARPSVLVD