Protein Info for LRK55_RS08670 in Rhodanobacter denitrificans MT42

Annotation: arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 5 to 624 (620 residues), 816.4 bits, E=8.6e-250
• PF02784: Orn_Arg_deC_N
  • amino acids 85 to 341 (257 residues), 141.5 bits, E=4.6e-45
• PF17810: Arg_decarb_HB
  • amino acids 366 to 448 (83 residues), 84.7 bits, E=6.7e-28
• PF17944: Arg_decarbox_C
  • amino acids 578 to 624 (47 residues), 42.9 bits, 8.2e-15

Best Hits

Swiss-Prot: 67% identical to SPEA_XANCP: Biosynthetic arginine decarboxylase (speA) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 67% identity to xop:PXO_03648)

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• superpathway of arginine and polyamine biosynthesis (12/17 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• spermidine biosynthesis III (2/4 steps found)
• superpathway of putrescine biosynthesis (2/4 steps found)
• superpathway of polyamine biosynthesis I (4/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (4/13 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Protein Sequence (629 amino acids)

>LRK55_RS08670 arginine decarboxylase (Rhodanobacter denitrificans MT42)
MANPWNTDAARHTYAVPHWSDGYVDVDDAGDIVMRPRGARGPSLSLPAIVERARADGLRL
PLLVRFPDILADRLARLQGAFAKAIDEWRYAGGYTAIYPIKVNQQRGVAGELVAAGTCGF
GLEAGSKPELMAVLAMARPGSIVICNGYKDREYIRLALIGKKLGLRVHIVIEKLSELDHV
FAEAKALGVEPLLGVRVRLASIGAGKWQNTGGDKGKFGLSPQQVLTLIERLDAAGLKHTL
KLQHFHMGSQISNVRDIANGMREATRYFVELSRMGVPLEIVDVGGGLGVDYEGSRSRSHN
SINYSIEQYAATIVQSLAEAVEAEGLAAPHILTEAGRAMTAHHAVMVVNVTEVEEVPAGA
IPPPCADEPAVLRRLRETWEELDRRPALELFHEAQHHLSEGQALYALGQLALADRARLDE
MYYAIANAVRARLLPAERSHRQALDELDEKLVDKYFVNFSVFESIPDVWAIGQIFPIAPI
ARLGEQPTRRGVIVDLTCDSDGRIDHYVDAEGVDVSLPLHALRAGESYRLGIFMVGAYQE
TLGDIHNLFGDTDAVNVRVDGDGYTFAHVRRGDTTDLMLDYVGYDLEALRASYRERIAAA
GLGGAEAAQLYDALDGGLTAYTYLAEDAD