Protein Info for LRK55_RS07560 in Rhodanobacter denitrificans MT42

Annotation: TonB-dependent vitamin B12 receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 615 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR01779: TonB-dependent vitamin B12 receptor" amino acids 1 to 612 (612 residues), 614.2 bits, see alignment E=1.4e-188 PF07715: Plug" amino acids 44 to 148 (105 residues), 101.6 bits, see alignment E=3.5e-33 PF00593: TonB_dep_Rec" amino acids 216 to 587 (372 residues), 153.3 bits, see alignment E=2.1e-48

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 49% identity to sml:Smlt0585)

Predicted SEED Role

"Outer membrane vitamin B12 receptor BtuB" in subsystem Coenzyme B12 biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (615 amino acids)

>LRK55_RS07560 TonB-dependent vitamin B12 receptor (Rhodanobacter denitrificans MT42)
MKKTLLAAALLGGTLAAHAADQNAASALAPVIVTATRTAITADQALSSVTVITRADIERL
QPLSVPDLLAGLPGLSFANSGGYGQQTSLFLRGSNSTHTLLLVDGVRVASVSAGLAAFEQ
IPVEQIERIEVVRGPRSSLYGADAIGGVIQIFTRRGTPGGGLQPSFSVTTGSNRLLRGQA
GLSGGDGHAWYNLGVGAQYTRGINACRIGAAEAFAGCFTDEPDRDAFRNKNLSASGGYRW
DNGAELTGTWLRSLGEIHFDGSYQNRSRTLQQVAGSSFSFNPLPAWKTTLSVGQNLDRYD
NYENRDFVGYIYSRRNQAAWQNDLSMADNQLLTLGVDWQGEHIDSDTGFLASRRNNTGGY
VQYQGTFGRHEVQLSARRDHNGQFGDHNTGAAAWGYHFDHGLRLSASYGSAFHAPTFNDL
YYPYGSGNPQLKPEQSRSAELGLSQQQDAWNWALNAYQTRIDQLIALDANYFPSNISKAR
IRGVEGQLGATLAGWQLQGYLTWLQPRNDDGGANDGKWLPRRPGRTARLDLDRRYGAFGV
GASVNAAGRSYDDAANRHPLAGYTTADLRASWHFAPDWQLEARLANVFDRHYETVWYFNQ
PGRSAFLTLRYSPAR