Protein Info for LRK55_RS07230 in Rhodanobacter denitrificans MT42

Annotation: NAD(P)/FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07992: Pyr_redox_2
  • amino acids 9 to 342 (334 residues), 173.1 bits, E=1.4e-54
• PF00070: Pyr_redox
  • amino acids 177 to 258 (82 residues), 41.8 bits, E=1.9e-14

Best Hits

KEGG orthology group: K03885, NADH dehydrogenase [EC: 1.6.99.3] (inferred from 52% identity to bgl:bglu_1g22570)

Predicted SEED Role

"NADH dehydrogenase (EC 1.6.99.3)" in subsystem Carboxysome or Respiratory dehydrogenases 1 (EC 1.6.99.3)

MetaCyc Pathways

• NADH to cytochrome bd oxidase electron transfer I (2/2 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• aerobic respiration III (alternative oxidase pathway) (2/3 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.99.3

Use Curated BLAST to search for 1.6.99.3

Protein Sequence (439 amino acids)

>LRK55_RS07230 NAD(P)/FAD-dependent oxidoreductase (Rhodanobacter denitrificans MT42)
MAVRPQLHRVVVVGGGVAGLEIATALGRRFRGERQRHGEGPSVTLVDHDTAHVWKPMLHT
IAAGTSDISQQQTPYQAQAHAAGFAFQMGEFAELDRTARELRLLPLRDRHGRVVIPERRV
RYDTLIIAVGSLVNDFGTPGVAEYCRVIDSRRQANAFNREIRVRVAQCLTQGKDLSIGIV
GGGATGVELAAELIRLKDAVVAYGGEELPTCLSVTLLEAGPRLLPAFPTNISTSVQGQLE
ALGVRVLTHTAVNSVTEDAFILNTKDRIPASLKVWAAGVKAPEFLAALDGLETTRGNQLV
VTASLCTTNDPHIFAVGDCSSLRLAGAERPLPPTAQVAHQQAQHLIRYLPDAVLHGRSVP
PFRYHDFGALVSLADYDAFGSLGDYGLMKSVTFRGRLAHFSHVLLYRRHQMQLHGVLRGW
LLWLIDRLNASARPTIRMD