Protein Info for LRK55_RS06015 in Rhodanobacter denitrificans MT42

Annotation: M3 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 730 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF01432: Peptidase_M3" amino acids 273 to 724 (452 residues), 428.7 bits, see alignment E=2.1e-132

Best Hits

Swiss-Prot: 46% identical to DCP_SALTY: Dipeptidyl carboxypeptidase (dcp) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01284, peptidyl-dipeptidase Dcp [EC: 3.4.15.5] (inferred from 72% identity to psu:Psesu_1369)

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

Compare fitness of predicted isozymes for: 3.4.15.5

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (730 amino acids)

>LRK55_RS06015 M3 family metallopeptidase (Rhodanobacter denitrificans MT42)
MKHPIALALAIALSGSMAACTDVGSDKNSSTPAQAHRDAVATDAGNPFFAESPLPLHYPQ
FDRIKDRDFAPAFDRGMAEQLKEVQAIAGNAEAPSFDNTIVALEKSGQILTRTSTVFFNL
VGADTNDARKALQAEYAPKLAAHRDAISLDPRLFARIQQLFDTRDSLGLDAEGVRLIERY
HTNFVRAGARLSDADKAQLKAINGELAKLGTQFSQNVLAEVNDSVVVVDTKEALAGLTDE
QIGAAAAAAKAKGLDGKYVIALLNTTGQPPEAQLQNRALRQRLHQASIARGSRGNPYDNT
AIVAQVLKLRAEKATMLGYPSYAAYVLADETAQTPEAVNAMLTQLAPPAVANAKREGAAL
QAMIDKEQAAKGEPTFALEPWDWAYYTEKLRAEKYDFDESQLKPYFEMKNVLENGVFHAA
GQLYGLSFKQRTDLPVYHPDVLVYDVYDADGKQLAIFLADMYARPSKRGGAWMNAYVEQS
ALTGNLPVVANHLNITKPASGPTLLTWDEVTTMFHEFGHALHGMFSNVQYPYFAGTSVPR
DFVEFPSQVNEMWADWPSVLANYARHYQTGTPMPKALLDKVLATVKFNQGFATTEYLGSA
MLDQSWHQIGVDRIPEAGGVVAFEAAALKANGTDYAPVPPRYRTPYFSHIMGGYAAGYYA
YLWSEVLDANTVEWIKANGGLTRANGDRFRATLLSRGGSKDALQLFRDFTGQEPKIEPLL
KRRGLDGAVD