Protein Info for LRK55_RS05035 in Rhodanobacter denitrificans MT42
Annotation: L-serine ammonia-lyase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 64% identical to SDHL_STRCO: L-serine dehydratase (sdaA) from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
KEGG orthology group: K01752, L-serine dehydratase [EC: 4.3.1.17] (inferred from 79% identity to psu:Psesu_0761)Predicted SEED Role
"L-serine dehydratase (EC 4.3.1.17)" in subsystem Glycine and Serine Utilization or Pyruvate Alanine Serine Interconversions (EC 4.3.1.17)
MetaCyc Pathways
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- D-serine degradation (3/3 steps found)
- L-cysteine degradation II (3/3 steps found)
- L-serine degradation (3/3 steps found)
- glycine degradation (3/3 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- L-tryptophan degradation II (via pyruvate) (2/3 steps found)
- glycine betaine degradation III (4/7 steps found)
- felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
- L-mimosine degradation (4/8 steps found)
- glycine betaine degradation I (4/8 steps found)
- glutathione-mediated detoxification I (3/8 steps found)
- purine nucleobases degradation II (anaerobic) (9/24 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.3.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (460 amino acids)
>LRK55_RS05035 L-serine ammonia-lyase (Rhodanobacter denitrificans MT42) MAVSVFDLFKIGIGPSSSHTVGPMRAAARFAEHWLEEKGVLDRVVRVRAELYGSLAMTGR GHGTDKAVLLGFEGQHPDTVDPDAIPATLERIRGTGRIRLLGRREIAFDEKADLVFNKRQ KLPFHTNGMRFSAYDADGSELASRDYYSVGGGFVVNTDEAAEDRIVADTTAQPYPFSSGD EMLALCKQHGLTIAQLMMANESVWRSEAETRAGLLTIWQAMQDCVTRGLRSPGTLPGGLH VARRAPAMAEELRNQPEAALKDPLTILDWVNLYALAVNEENAAGGRVVTAPTNGAAGIVP AVGHYYLRFCPKADENGIIDYLLTAAAIGILYKENASISGAEVGCQGEVGVACSMAAGGL TAALGGNVMQVENAAEIGMEHNLGLTCDPIGGLVQIPCIERNAMGSVKAINASRMALKSD GKHRVSLDKVIKTMRDTGRDMKDKYKETSRGGLAVNVIEC