Protein Info for LRK55_RS04030 in Rhodanobacter denitrificans MT42

Annotation: pyrroline-5-carboxylate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03807: F420_oxidored
  • amino acids 3 to 98 (96 residues), 59.9 bits, E=3.1e-20
• TIGR00112: pyrroline-5-carboxylate reductase
  • amino acids 4 to 266 (263 residues), 278.2 bits, E=3.9e-87
• PF14748: P5CR_dimer
  • amino acids 162 to 266 (105 residues), 126.7 bits, E=4.5e-41

Best Hits

Swiss-Prot: 40% identical to P5CR_VIBAL: Pyrroline-5-carboxylate reductase (proC) from Vibrio alginolyticus

KEGG orthology group: K00286, pyrroline-5-carboxylate reductase [EC: 1.5.1.2] (inferred from 59% identity to xoo:XOO1416)

Predicted SEED Role

"Pyrroline-5-carboxylate reductase (EC 1.5.1.2)" in subsystem Proline Synthesis (EC 1.5.1.2)

MetaCyc Pathways

• L-arginine degradation VI (arginase 2 pathway) (4/4 steps found)
• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-proline biosynthesis III (from L-ornithine) (3/3 steps found)
• L-arginine degradation XIII (reductive Stickland reaction) (3/5 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.1.2

Protein Sequence (274 amino acids)

>LRK55_RS04030 pyrroline-5-carboxylate reductase (Rhodanobacter denitrificans MT42)
MTRLAFIGGGNMARSLIGGLLNTGVAPATLSVAEPLAEARQALGRDFGIACYAENRLAVA
DAEVILLAVKPQVMPAIHADLRDILQRHRPLLISIAAGVRLDQLERWFGSGLPIVRCMPN
TPALIGAGATGLCANHRVSPAQKAQAQHILDAAGITRWIDDEALMDTVTALSGSGPAYFF
ALVEALEAAAVAQGLPRDTARALAAQTCLGAGRMLVEGGEDPAALRQRVTSPHGTTQAAL
ESFAADGLPHIVARAVAAATRRGVELAAELDQLP